Dr. Oludare M. OGUNYEMI



Name:Oludare M. OGUNYEMI
Designation: Assistant Lecturer
 Faculty: Basic Medical Sciences
 Department: Biochemistry
Phone Number: +2348066699567

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Oludare Michael Ogunyemi, PhD

Dr. O. M. Ogunyemi completed his Ph.D. studies in 2023 at the Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria. During his post graduate studies he received several awards. He was a recipient of the Ekiti State Postgraduate Scholarship Bursary Award (2012). He was also a recipient of the African-German Network of Excellence in Science (AGNES) Mobility Grant supported by the German Federal Ministry of Education and Research (BMBF) and the Alexander von Humboldt Foundation (AvH) (2016), tenable at the Food Security and Safety Research Niche, North-West University, Mafikeng, South Africa. Before joining the service of the University of Ibadan, Dr Ogunyemi enjoyed a rich experience in research and teaching. He was a Research Technologist as a contract staff member at the Medical Genetics and Bioethics Laboratories, Institute of Advance Medical Research and Training (IAMRAT), Ibadan, Nigeria (2014). Later he was appointed as a Lecturer in the Department of Biosciences, Salem University, Lokoja (2018-2022) where he co-founded the Human Nutraceuticals and Bioinformatics Research Unit. Briefly, he was a Lecturer in the Department of Biochemistry, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Nigeria (2022-2023).

Area of Specialisation:

Dr Ogunyemi recently completed his postgraduate training in the area of Nutritional and Industrial Biochemistry. He currently applies the molecular modeling and biochemical techniques to identify promising nutraceuticals and drug leads from African herbs, spices and medicinal plants. This has led to publication of thirty (30) well indexed and highly cited original research articles. Dr. Ogunyemi looks forward to post-doctoral opportunities for self-development in the areas of Structural biochemistry, Biophysics, Bioinformatics, Computational modeling and Nutraceutical/ Drug design.


On-going research focuses on integrating structural bioinformatics, molecular modeling, artificial intelligence, biochemical assays and biophysical studies for prospecting and developing bioactive ingredients and nutraceuticals from food herbs, spices and other natural resources. So far, several in silico hits have been suggested for future experimental and preclinical evaluation.


Selected Publications

1. Ogunyemi, M., Gyebi, G. A., Ibrahim, I. M., Esan, A. M., Olaiya, C. O., Soliman, M. M., and Batiha, G. E. (2023). Identification of promising multi-targeting inhibitors of obesity from Vernonia amygdalina through computational analysis. Molecular Diversity. 27, 1-25. doi: 10.1007/s11030-022-10397-6.

2. Gyebi, G. A., Ogunyemi, O. M., Adefolalu, A. A., López-Pastor, J. F., Banegas-Luna, A. J., Rodríguez-Martínez, A., Pérez-Sánchez, H., Adegunloye, A. P., Ogunro, O. B., and Afolabi, S. O. (2023). Antimalarial phytochemicals as potential inhibitors of SARS-CoV-2 guanine N7-methyltransferase (nsp 14): an integrated computational approach. Journal of Biomolecular Structure and Dynamics, 41:11,5022-5044. doi: 1016/j.molstruc.2022.133019.

3. Femi Olawale, Kolawole Olofinsan, Oludare M. Ogunyemi, Kayode O. Karigidi, Gideon A. Gyebi, Ibrahim M. Ibrahim, and Opeyemi Iwaloye (2023). Deciphering the therapeutic role of Kigelia africana fruit in erectile dysfunction through metabolite profiling and molecular modelling, Informatics in Medicine Unlocked, 37,101190, https://doi.org/10.1016/j.imu.2023.101190

4. Joy A Adetunji, Oludare M Ogunyemi, Gideon A Gyebi, Anuoluwapo E Adewumi and Charles O Olaiya (2023). Atomistic simulations suggest dietary flavonoids from Beta vulgaris (beet) as promising inhibitors of human angiotensin-converting enzyme and 2-alpha-adrenergic receptors in hypertension. Bioinformatics Advances. 3(1) https://doi.org/10.1093/bioadv/vbad133

5. Gideon A Gyebi, Joseph C Ejoh, Oludare M Ogunyemi, Auza Moses Ibrahim, Ibrahim M Ibrahim, Saheed O Afolabi, Gabriel O Anyanwu, Rotimi J Ojo, Olalekan B Ogunro, Badriyah S Alotaibi, and Gaber El-Saber Batiha (2023). Probing the multitargeting potential of n-hexane fraction of Gongronema latifolium leaves in neurodegeneration via in vitro, GC–MS and in silico Future Journal of Pharmaceutical Sciences 9:84. https://doi.org/10.1186/s43094-023-00536-7

6. Anifowose LO, Paimo OK, Adegboyega FN, Ogunyemi OM, Akano RO, Hammad SF, and Ghazy MA (2023). Molecular docking appraisal of Dysphania ambrosioides phytochemicals as potential inhibitor of a key triple-negative breast cancer driver gene (2023). In Silico Pharmacol. 11. doi: 10.1007/s40203-023-00152-6.

7. Gideon Ampoma Gyebi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Olalekan B. Ogunro, Saheed O. Afolabi, Rotimi J. Ojo, Gabriel O. Anyanwu, Gaber El-Saber Batiha and Joseph O. Adebayo (2023). Identification of potential inhibitors of cholinergic and β-secretase enzymes from phytochemicals derived from Gongronema latifolium Benth leaf: an integrated computational analysis. Molecular Diversity. https://doi.org/10.1007/s11030-023-10658-y

8. Ogunyemi, O.M., Gyebi, G., Saheed, A., Paul, J., Nwaneri-Chidozie, V., Olorundare, O., Adebayo, J., Koketsu, M., Aljarba, N., Alkahtani, S., Batiha, G., and Olaiya, C. (2022), Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth. Mol. Biosci. 9:866719. doi: 10.3389/fmolb.2022.86671.

9. Gaber El-Saber Batiha, Oludare M. Ogunyemi, Hazem M. Shaheen, Funso Raphael Kutu, Charles O. Olaiya, Sabatier Jean-Marc and Michel De Waard (2022). Rhus coriaria L. (Sumac), a versatile and resourceful food spice with cornucopia of polyphenols. Molecules 27(16), 5179; https://doi.org/10.3390/molecules27165179.

10. Gyebi, A., Ogunyemi, O. M., Ibrahim M. I., Afolabi, S. O., Ojo­­, R. J., Uju E. I. and Adebayo, J. O. (2022). Inhibitory potentials of phytocompounds from Ocimum gratissimum against anti-apoptotic BCL-2 proteins associated with cancer: An integrated computational study. Egyptian Journal of Basic and Applied Sciences 9 (1): 588-608.

11. Femi Olawale, Oludare Ogunyemi and Ibukun Mary Folorunso (2022). Repurposing clinically approved drugs as Wee1 checkpoint kinase inhibitors: an in silico investigation integrating molecular docking, ensemble QSAR modelling and molecular dynamics simulation. Molecular Simulation. DOI: 10.1080/08927022.2022.2101673.

12. Gyebi, G. A., Ogunyemi, O. M., Adefolalu, A. A., Rodríguez-Martínez, A., López-Pastor, J. F., Banegas-Luna, A. J., Pérez-Sánchez, H., Adegunloye, A. P., Ogunro, O. B., and Afolabi, S. O. (2022). African derived phytocompounds may interfere with SARS-CoV-2 RNA capping machinery via inhibition of 2′-O-ribose methyltransferase: An in silico perspective. Journal of Molecular Structure, 1262, 133019. DOI: 1016/j.molstruc.2022.133019

13. Olawale, F., Iwaloye, O., Olofinsan, K., Ogunyemi, O. M., Gyebi, G. A., and Ibrahim, I. M. (2022). Homology modelling, vHTS, pharmacophore, molecular docking and molecular dynamics studies for the identification of natural compound-derived inhibitor of MRP3 in acute leukaemia treatment. Chemical Papers. doi: 10.1007/s11696-022-02128-w

14. Tom-Otu, M. O., Omowaye, O. S., Makolo, D., Ayodele , P. F., Ogunyemi, O. M., Fabusiwa, M., and Fabusiwa, M. (2022). In Silico and In Vitro Antimicrobial Testing of Aqueous Extract of Vernonia amygdalina against Escherichia coli Isolated from Wistar Rats Infected with Trypanosoma congolense. Open Journal of Bioscience Research (ISSN: 2734-2069), 3(2), 1-16. https://doi.org/10.52417/ojbr.v3i2.391

15. Gyebi, G. A., Elfiky, A. A., Ogunyemi, O. M., Ibrahim, I. M., Adegunloye, A. P., Adebayo, J. O., Olaiya, C.O., Ocheje, J. and Fabusiwa, M. M. (2021). Structure-based virtual screening suggests inhibitors of 3-Chymotrypsin-Like Protease of SARS-CoV-2 from Vernonia amygdalina and Occinum gratissimum. Computers in Biology and Medicine 136: https://doi.org/10.1016/j.compbiomed.2021.104671

16. Gyebi, G. A., Ogunyemi, O. M., Ibrahim, I. M., Afolabi, S. O., and Adebayo, J. O. (2021). Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes: An in silico perspective. Computers in Biology and Medicine, 134, 104406 1016/j.compbiomed.2021.104406.

17. Ogunyemi, O. M., Gyebi, G. A., Ibrahim, I. M., Olaiya, C. O., Ocheje, J. O., Fabusiwa, M. M., and Adebayo, J. O. (2021). Dietary stigmastane-type saponins as promising dual-target directed inhibitors of SARS-CoV-2 proteases: a structure-based screening. RSC Advances, 11(53), 33380-33398. DOI: 1039/d1ra05976a

18. Ogunyemi, M.O., Gyebi G. A., Shaibu R.O. (2021) Antioxidant, nutritional and physicochemical quality of yoghurt produced from milk-based fermentation mix enhanced with food spices. Croatian Journal of Food Science and Technology 17508/CJFST.2021.13.2.10.

19. Gyebi, G. A., Ogunyemi, O. M., Ibrahim M. I., Ogunro, O. B., Adegunloye, A. P., and Afolabi, S. O. (2020). SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids. Journal of Genetic Engineering and Biotechnology. 19:113. 10.1186/s43141-021-00209-z.

20. Gyebi, G. A., Ogunro, O. B., Adegunloye, A. P., Ogunyemi, O. M., and Afolabi, S. O. (2020). Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): An in silico screening of alkaloids and terpenoids from African medicinal plants. Journal of Biomolecular Structure and Dynamics, 39(9) 3396-3408 1080/07391102.2020.1764868.

21. Gyebi, G. A., Adegunloye, A. P., Ibrahim M. I., Ogunyemi, O. M., Ogunro, O. B., and Afolabi, S. O. (2020). Prevention of SARS-CoV-2 Cell Entry: Insight from In silico Interaction of Drug-like Alkaloids with Spike Glycoprotein, human ACE2 and TMPRSS2. Journal of Biomolecular Structure and Dynamics, 40 (5), 2121-2145. 1080/07391102.2020.1835726.

22. Ogunyemi O. M., Gyebi A.G., Adebayo J.O., Oguntola J.A., Olaiya C.O. (2020) Marsectohexol and other pregnane phytochemicals derived from Gongronema latifolium as α-amylase and α-glucosidase inhibitors: in vitro and molecular docking studies SN Applied Science. 2(12), 1-11. 1007/s42452-020-03951-0.

23. Ogunyemi, O. M., Gyebi, G. A., Elfiky, A. A., Afolabi, S. O., Ogunro, O. B., Adegunloye, A. P., and Ibrahim, I. M. (2020). Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective. Antiviral Chemistry and Chemotherapy, 28, 2040206620984076.

24. Oso B.J and Ogunyemi O.M (2020). Assessment of in vitro biological properties of aqueous extracts of Murraya koenigii (L.) Spreng, Thymus vulgaris L., and Ocimum gratissimum L. leaves. Croatian Journal of Food Science and Technology. DOI: 10.17508/CJFST.2020.12.2.10

25. Usman A. A., Ogunyemi O. M., Effiong M. O., and Usman G. O (2020). Effect of dehusking on the chemical and nutritional composition of jack bean seed. Salem University Journal of Life Sciences: Vol. 2, No.1, pp 80-93. Nigeria.

26. Ogunyemi O.M., Gyebi G.A., Shaibu O.R., Ozonwa O. J. & Olaiya C.O. (2020) Enhancement Of Antioxidant Potential Of Yoghurt With Natural Additives: Preliminary Sensory And In Vitro Antioxidant Analyses. Salem University Journal of Life Sciences 2(1) 1-17.

27. Gyebi G. A., Ocheje J. A., Ogunyemi, O.M. (2019) Molecular docking studies of bioactive compounds from clove (Syzygium aromaticum) on metabolic regulators in cancer. Salem University Journal of Life Sciences 1(1) 1-18.

28. Olaiya C.O, Ogunyemi O.M, Karigidi K.O (2015). Biotechnological Strategies for Enhancing the Nutritive and Nutraceutical Values of Tomato (Solanum lycopersicon). The Annals of the University Dunarea de Jos of Galati Fascicle VI – Food Technology. 39(2), 9-19.

29. Olaiya C.O, Choudhary M.I, Ogunyemi O.M, Nwauzoma A.B. (2013). Nutraceuticals from Bitter Leaf (Vernonia amygdalina) Protects against Cadmium Chloride- induced Hypertension in Albino Rats. Nature and Science. 11(6):136-145



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