Dr. Olubukola T. OYEBODE



Name:Olubukola T. OYEBODE
Designation: Lecturer I
 Faculty:Basic Medical Sciences
 Department: Biochemistry
Phone Number: +2347031349454

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Dr Oyebode is a researcher and lecturer at the Biomembrane Unit of the Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria. She teaches Biochemistry at both the undergraduate and graduate levels in the area of Membrane Biochemistryand Biotechnology and has published a number of articles in peer-reviewed journals with a good representation in top-quartile rated journals in the field. She is an emerging researcher in the field of Biochemistry with passion for regulated cell death, mitochondria and drug discovery. She is particularly interested in pharmacological targeting of mitochondria via manipulation of regulated cell death pathways for disease therapy and intend I intend to use molecular biology and contemporary techniques of biochemistry to unravel the molecular basis of diseases for the purpose of therapy development.


Current Research

Title: Characterizing the role of human branched chain amino acid transferases (BCAT) in regulated cell death pathways in cancer cells
Funder: University of Derby, UK.

Brief Summary

Dysregulation of Branched-Chain Amino acid Aminotransferase (BCAT), the enzyme which catalyzes the transamination of branched-chain amino acids (BCAAs) is implicated in tumour growth and development. Two BCAT isozymes have been identified in humans, a mitochondrial form known as BCATm/BCAT2, and a cytosolic form known as BCATc/BCAT1. Emerging evidence reveal that increased BCAT 1 and 2 activities which underscores the survival and proliferation of cancer cells suppresses cell death, a process vital for elimination of transformed cells. Hence, BCAT has been identified as a risk factor in multiple cancers and several disorders and has therefore become a potential therapeutic target with clinical implications. However, the role of BCAT 1and 2 in regulated cell death pathways is not clearly defined as well as the contribution of mitochondria in BCAT-induced cell proliferation. The aim of this study is to investigate the mode of cell death regulated by BCAT in promoting cell proliferation and metastasis and to define the role of mitochondria in this regard. The outcome of this study will help our understanding of BCAT dynamics and uncover additional therapeutic targets which will help in design of appropriate BCAT inhibitors for anticancer therapy.

Role: Lead Researcher

Collaborators: Dr Jonathon Hull. University of the West of England, Bristol,UK
Prof Myra Conway.University of Derby, UK

Completed Research

Modulation of mitochondrial-mediated apoptosis by partially purified fractions of CalliandraportoricensisBenth


Selected Publications

1. Oyebode, O.T., Abolaji, A.O., Faleke H.F., and Olorunsogo, O. O. (2021). Methanol fraction of Ficusmucoso inhibits iron-induced oxidative damage and mitochondrial dysfunction in Drosophila melanogaster. Drug and Chemical Toxicology. https://doi.org/10.1080/01480545.2021.1979997

2. Oyebode, O.T., Olanlokun, J.O., Salami, O., Obi I., Bodede, O., Prinsloo, G and Olorunsogo, O. O (2021). Terpene-rich fractions of Ficusmucoso (Welw) modulate lipopolysaccharide-induced inflammatory mediators and aberrant permeability of the inner mitochondrial membrane in murine animal model. Inflammopharmacology.
https://doi.org/ 10.1007/s10787-021-00876-x

3. Bello, I. J., Oyebode, O.T., Olanlokun, J.O., Omodara T.O and Olorunsogo, O. O. (2021). Plumbagin induces testicular damage via mitochondrial-dependent cell death. Chemico-Biological InteractionsNo. 7: 109 – 115. https://doi.org/10.1016/j.cbi.2021.109582

4. Oyebode, O.T., Olowofolahan A.O., Olorunsogo, O. O. (2021) Toxic effects of unripe Carica papaya (Linn) fruit extract on Healthy rat liver mitochondria. Traditional and Integrative MedicineVol. 6. No. 2: 126 -137.https://doi.org/10.18502/tim.v6i2.6789

5. OlowofolahanA.O., OyebodeO.T. and OlorunsogoO.O. (2020) Methyl palmitate
reversed estradiol benzoate-induced endometrial hyperplasia in female rats. Toxicology Mechanisms and Methods, https://doi.org/10.1080/15376516.2020.1827329.

6. Oyebode, O.T., Giwa, O. D. and Olorunsogo, O.O. (2020). Comparative effects of galactose-induced aging on mitochondrial permeability transition in rat liver and testis. Toxicology Mechanisms and Methods, https://doi.org/10.1080/15376516.2020.1755921

7. Oyebode, O.T., Abolaji, A.O., Oluwadare, J.O., Adedara A. O and Olorunsogo, O. O. (2020). Apigenin ameliorates D-galactose-induced lifespan shortening effects via antioxidative activity and inhibition of mitochondrial-dependent apoptosis in Drosophila melanogaster.Journal of Functional Foods Vol 69:103957. https://doi.org/10.1016/j.jff.2020.103957

8. Oyebode, O.T., Obiekwe, M. and Olorunsogo, O.O. (2020). Protective effects of Alpha stone, a poly-herbal formulation, on Monosodium glutamate-induced uterine hyperplasia in female Wistar rats: Journal of Ayurveda and Integrative Medicine. Vol 11: 217-223. https://doi.org/10.1016/j.jaim.2019.05.001

9. Oyebode, O.T., Owumi, S.E., Oyelere, A.K., and Olorunsogo, O.O. (2019). CalliandraportoricensisBenth exhibits anticancer effects via alteration of Bax/Bcl-2 ratio and growth arrest in prostate LNCaP cells. Journal of Ethnopharmacology Vol 233: 64-72. https://doi.org/10.1016/j.jep.2018.12.020. PMID: 30580026.

10. Oyebode, O.T., Adebiyi, O.R.,and Olorunsogo, O.O. (2019). Toxicity of some broad spectrum antibacterials in rat liver: The role of mitochondrial membrane permeability transition pore. Toxicological Mechanisms and Methods. Vol 1: 1-31. https://doi.org/10.1080/15376516.2018.1528651

11. Oyebode, O.T., Ogunbiyi, F.O. and Olorunsogo, O.O. (2019). Opening of liver mitochondrial permeability transition pore in streptozotocin-induced diabetic rats and its inhibition by methanol fraction of Ficusmucuso (Welw) root bark. Journal of Integrative Medicine. Vol 17: 446-454. https://doi.org/10.1016/j.joim.2019.10.001

12. Oyebode, O.T.,Akinyelu, J.O., Oamen, E.O and Olorunsogo, O.O. (2018). Methanol fraction of Calliandraportoricensisroot bark activates caspases via alteration in mitochondrial viability in vivo. Journal of Herbmed PharmacologyVol 7. No. 4: 251-258. https://doi.org/10.15171/jhp.2018.38

13. Oyebode, O.T., Akinbusuyi, O.T., Akintimehin, S.E. and Olorunsogo, O.O. (2017). Modulation of cytochrome C release and opening of the mitochondrial Permeability Transition pore by Calliandraportoricensis (Benth) Root Bark Methanol Extract. European Journal of Medicinal PlantsVol. 20. No. 1: 1-14. https://doi.org/10.9734/EJMP/2017/35211

14. Oyebode, O.T.,Owaboye, W.R., Akinbisoye, O.F. and Olorunsogo, O.O. (2017). Evaluation of the effects of fractions of Jatropha curcas (Linn) leaves on mitochondrial permeability transition in rat liver. Annual Research & Review in Biology Vol. 16. No. 2: 1-15. https://doi.org/10.9734/arrb/2017/35882

15. Adaramoye, O., Erguen, B., Oyebode, O., Nitzsche, B., Hopfner, M., Jung, K. and Rabien, A. 2015). Antioxidant, Antiangiogenic and Antiproliferative Activities of Root Methanol Extract of Calliandraportoricensisin Human Prostate Cancer Cells. Journal of Integrative Medicine Vol. 13. No 3: 185-193. https://doi.org/10.1016/S2095-4964(15)60175-3. PMID: 26006031

16. Oyebode, O.T.,Odejide, T.T., Kukoyi, A.J., Adebisi, L.A. and Olorunsogo, O.O. (2012). Effects of Different Fractions of CalliandraportoricensisRoot Bark on Isolated Rat Liver Mitochondrial Membrane Permeability Transition Pore.African Journal of Medicine and Medical Sciences Vol. 2. No. 41: 399- 409. PMID: 23672105.https://www.ncbi.nlm.nih.gov/pubmed/23672105



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oyebode interestsandhobbies

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