Dr. Moses O. ADEWUMI

Basic Information


Name: Dr. Moses O. ADEWUMI


EmailThis email address is being protected from spambots. You need JavaScript enabled to view it.


 Designation: Reader

 Brief Biography:



Contributions to Science


 Earliest cases of HIV in Nigeria were reported in 1985. By 2001 HIV prevalence had increased to a highest 5.8%. Lack of prompt and effective HIV diagnosis among other factors were implicated in the unabated spread. As a doctoral degree student in 2001, I became part of the US funded AIDS Prevention Initiative Program in Nigeria (APIN) team and worked both as a Counsellor and Phlebotomist on the field and Scientist for laboratory analysis of various samples. We evaluated varied HIV diagnostic test kits imported to the country to ascertain reliability of test results, and subsequently highlighted the impacts of inaccurate testing on spread of HIV in Nigeria. Our work helped in fashioning an effective HIV testing algorithm for the country. In Nigeria with a population of about 160 million, the seemly low (in comparison to other developing countries) prevalence rate of 5.8% translated to a third highest in the number of HIV infected individuals globally. Consequently, availability and affordability of branded antiretroviral therapy (ART) became a challenge. In response to the challenge, I monitored HIV infected individuals on generic highly active antiretroviral therapy (HAART) using plasma viral load and CD4 T-cell levels over a period of at least twenty-four months. The study was carried out to help ascertain virologic and immunologic responses and effectiveness of available generic HAART. Outcome of the study helped in the upward review of baseline CD4 for ART initiation, and administration of generic HAART to overwhelming population of HIV infected individuals in the country. In the course of the study, it was noted that significant proportion of the patients presented late to the hospital, and often with opportunistic infections (OIs) like cryptoccocal meningitis. Consequently, a number of the patients had suspected HIV-associated neurological infections. In response to these observations, the ongoing research works in UNC, Chapel Hill and Harvard, Boston were developed to define possible contributions of HIV compartmentalization in the central nervous system (CNS) to the observed disease condition. The studies aimed to ascertain viral diversity and CNS compartmentalization in non-B HIV-1 and HIV-1 and 2 infected patients from Nigeria and Mali respectively.


 Hepatitis B Virus

 Hepatitis B virus (HBV) infection remained a public health challenge in Nigeria, and lack of effective diagnostic and intervention schemes were identified as major factors for its spread. My early work as independent researcher on determination of prevalence of HBV among HIV naïve and infected population confirmed endemicity and comparable rates of HBV infection independent of HIV-status in Nigeria. Consequent to the outcome of the study, it was recommended that prevention measures including access to prompt and appropriate diagnosis of HBV should be promoted regardless of HIV status in the population. Also, consequent to the findings a team of researchers was formed to collaborate with the aim of studying epidemiology and the ‘evolutionary dynamics of hepatitis in Nigeria’ (EDHIN). Our first study involved evaluation of HBV diagnostic parameters among over one thousand participants from varied populations to confirm endemicity and isolate circulating strains of the virus in the country. We reported HBV Immune Escape Mutant (IEM) for the first time in Nigeria. The first documented case was from a pregnant woman, and subsequently we isolated similar strains from apparently healthy community dwellers. We highlighted consequences of breakthrough infections by IEMs in vaccinated population and the spread of the mutant HBV variants in the country at large.



Nigeria was one of the few countries with uninterrupted wild poliovirus transmission after the year 2000 global target for polio eradication. Endemicity and unabated wild polio transmission in the country was in contrast to huge investments on expanded program on immunization (EPI) by the government and foreign partners, and statement of success reported in vaccine coverage by the Federal Ministry of Health (FMoH). It was an opportunity for me as a graduate student to investigate and verify the claimed success in vaccination program. Immunity to poliovirus serotypes was evaluated among children in Southwestern region of Nigeria, and subsequently in other regions alongside some colleagues. Our studies confirmed low herd immunity to poliovirus in the population, and subsequently recommended re-evaluation and monitoring of vaccination procedure, especially in the hard-to-reach areas in the country. During the end phase of global poliovirus eradication, I participated as a Consultant in the WHO funded poliovirus laboratory containment program in Nigeria. With poliovirus in control globally, attentions have been drawn to other enteroviruses of clinical importance. In response to this, I have been in collaboration with colleagues, and together we have evaluated the WHO diagnostic algorithms for poliovirus isolation and identification, and its implications on the perception of enterovirus diversity in the region. As a Visiting Scholar in UNC, Chapel Hill, a collaborative study was initiated with my host to develop deep sequencing-based protocol for isolation and identification of enteroviruses. When completed the protocol will help improve enteroviruses investigation in Nigeria and globally.




A. Thesis and Dissertation

  1.            Some Aspects of the Biology of Rastrococcus sp. (Homoptera: Pseudococcidae) infesting Acalypha sp. – November, 1992
  2.            Antibodies to Poliovirus types 1, 2 and 3 in Children in Oyo and Ogun States, Nigeria – September, 2001
  3.          Human T4-Lymphocyte and Plasma HIV-1 RNA Changes among Infected Individuals on Generic Highly Active Antiretroviral Therapy in Nigeria – June, 2010

B. Journal Articles

1. Opaleye O.O., Adewumi M.O., Donbraye E., Bakarey A.S., Odaibo G.N., Olaleye D.O.  Prevalence  of Measles Neutralizing Antibody in Children under 15 years in southwestern Nigeria.  Afr. J. Clin. Exper. Microbiol.2005; 6(1):60-63

2. Adewumi, M.O., Donbraye, E., Odaibo, G.N., Bakarey, A.S., Opaleye, O.O. and Olaleye, D.O.  Neutralizing Antibodies against poliovirus serotypes among children in southwestern Nigeria. Journal of Tropical Paediatrics. 2006; 52(2):92-95.

3.  Odaibo, G.N., Donbraye, E., Adewumi, M.O., Bakarey, A.S., Ibeh M.A. and Olaleye, D.O. Reliability of testing and potential impact on HIV prevention in Nigeria. African Journal of Medicine and Medical Sciences. 2006;35, Suppl. 131-135 

4. Sule W.F., Adewumi M.O. and Samuel T.C. (2009). Human immunodeficiency virus (HIV) specific antibodies among married pregnant women and female commercial sex workers attending voluntary counseling and HIV testing (VCT) centre in Abuja, Nigeria. African Journal of Biotechnology Vol. 8 (6), pp. 941-948, 20 March, 2009

5. W.F. Sule, S. C. Enemuor, M. O. Adewumi and O. C. Attah (2009). Traditional crop farmers in Kogi East, Nigeria elucidate elevated HIV and AIDS prevalence level during a five-year study period. African Journal of Microbiology Research Vol. 3(4) pp. 128-132 April, 2009

6. Donbraye, E., Adewumi, M.O., Odaibo, G.N., Bakarey, A.S., Opaleye, O. O. and Olaleye, D.O. Evaluation of Immunity against poliovirus serotypes among children in riverine areas of Delta State, Nigeria.  Afr. J. Clin. Exper. Microbiol. Vol. 12(2) pp72-75 May, 2011.

7. Adaramoye O.A., Adesanoye O.A., Adewumi O.M., Akanni O., Studies on the toxicological effect of nevirapine, an antiretroviral drug on the liver, kidney and testis of male Wistar rats. Hum Exp Toxicol. 2012 Jul;31(7):676-85. Epub 2011 Oct 25.

8. Adaramoye O.A., Adewumi O.M., Adesanoye O.A., Faokunla O.O. and Farombi E.O.  Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats: protective role of vitamin E. J Basic Clin Physiol Pharmacol. 2012 Apr 26; 23 (2):69-75. doi: 10.1515/jbcpp.2011.0042.

9. Japhet M.O., Adesina O.A., Donbraye E., Adewumi M.O., Hepatitis B Core IgM Antibody (anti-HBcIgM) Among Hepatitis B Surface Antigen (HBsAg) Negative Blood Donors in Nigeria.  Virology Journal 8:513  doi:10.1186/1743-422X-8-513

10. W.F. Sule, A.T. Kajogbola, M.O. Adewumi (2013) High Prevalence of Anti-Hepatitis A Virus Immunoglobulin G antibody among Healthcare Facility Attedees in Osogbo, Nigeria.  Journal of Immunoassay and Immunochemistry 34:1, 75-82http://dx.doi.org/10.1080/15321819.2012.683502

11. Adewumi M.O., Olusanya R.B., Oladunjoye B.A. and Adeniji J.A. (2013) Qualitative and Quantitative Analysis of Rubella IgG Antibody among Pregnant Women in Ibadan, Nigeria. Afr. J. Clin. Exper. Microbiol 14(1): 40-44  http://dx.doi.org/10.4314/ajcem.v14i1.9

12. Adeniji J.A., Onoja A.B., Adewumi M.O. (2014) Poliovirus neutralization antibody dynamics among children in a north central and south-western Nigeria states J Immunoassay Immunochem. PMID: 24568629 Feb 25, 2014. [Epub ahead of print]

13. Adegboye O.A., Adegboye A.A, Adewumi M.O., Sule W.F (2014) Low and zero prevalence rates of anti-measles virus immunoglobulin G in mothers and their infants respectively in health centers in Osogbo, Nigeria. British Journal of Medicine and Medical Research 4(32): 5107-5115

14. Adewumi M.O., Donbraye E., Sule W.F., Olaniran O (2014) HBV infection among HIV-infected cohort and HIV-negative hospital attendees in southwestern Nigeria African Journal of Infectious Diseases 9(1): 14–17.

15. Adeniji J.A., Osundare F.A., Adewumi M.O., Onoja A.B., Fagbami A.H.(2014) Immunity to poliovirus serotypes in children population of selected communities in south-west Nigeria African Journal of Infectious Diseases (2015) 9(1): 1 – 5.

16. Abraham-O.J., Adewumi M.O., Onoja A.B., Suleiman I.,Sulaiman, L.K., Ahmed S. J. and Jagboro, S.T. (2014). Seroprevalence of Infectious Bursal Disease Virus in Local Chickens in Udu Local Government Area of Delta State, South East Nigeria (Accepted for publication in Journal of Immunoassay and Immunochemistry - July 2014)

17. Adewumi M.O., Odaibo G.N., Olaleye O.D. (2014) Efficacy of generic highly active antiretroviral therapy in HIV-1 infected individuals in Nigeria (Accepted for publication in Journal of Immunoassay and Immunochemistry).

18. Adewumi M.O., Olayinka O.A., Olusola B.A, Faleye T.O.C, Sule W.F, Adesina Olubukola (2014). Epidemiological evaluation of rubella virus infection among pregnant women in Ibadan, Nigeria (In press).

19.Faleye T.O.C., Adewumi M.O., Ifeorah I.M, Omoruyi E.C., Bakarey S.A., Akere Adegboyega, Awokunle Funmilola, Ajibola H.O., Makanjuola D.O., Adeniji J.A. (2014). Detection of hepatits B virus isolates with mutations associated with immune escape mutants in Ibadan, Southwestern Nigeria (Accepted for publication in SpringerPlus Open Journal, October, 2014).


C. Abstracts Presented at Conferences

     1.      Odaibo G.N., Jegede S.A., Fayemiwo S.A., Agboola A., Aina O., Adewumi M., Donbraye E., Sankale J.L., Kanki P. and Olaleye D.O. (2003): HIV-1 infection among Non-injection drug users in Ibadan, Nigeria.  13th International Conference on AIDS and STIs in Africa. September 21st-26th, 2003. Abstract #368380 (Oral presentation) P.58.

     2.       Odaibo G.N., Sankale J.L., Jegede S.A., Ekanem E.E., Ojebode T.O., Aina O., Adewumi M., Donbraye E., Ajuwon J.A., Orubuloye I.O., Kanki P. and Olaleye D.O. (2003): Community-based Survey of HIV Infection in Oyo State, Nigeria.  13th International Conference on AIDS and STIs in Africa. September 21st-26th, 2003. Abstract #446844 (Oral presentation) P.183.

     3.      Olaleye D.O., Sankale J.L., Odaibo G.N., Ekanem E.E., Aina O., Donbraye E., Adewumi M., Forbi J. and Kanki P. (2003): Circulating HIV-1 subtypes and recombinants in South Western Nigeria.  13th International Conference on AIDS and STIs in Africa. September 21st-26th, 2003. Abstract #989353 (Poster presentation) P.294.

      4.      Odaibo G.N., Donbraye E., Adewumi M., Bakarey A., Ibeh M., Sankale J.L., Olaleye D.O. and  Kanki P. (2006): Reliability of testing and potential impact on HIV prevention in Nigeria. 16th International AIDS Conference 2006, August 13-18: Abstract number: MoPEO109

     5.      Adewumi M.O., Odaibo G.N., Donbraye E., Bakarey A.S. and Olaleye, D.O. (2008). Some immunological and virological parameters in HIV infected individuals on HAART in southwestern, Nigeria. 1st Unibadan Conference of Biomedical Research, August, 26-29, 2008. Abstract number:B51(Oral presentation) P.77

     6.      Adewumi M.O., Olusanya R.B., Oladunjoye B.A., Adeniji J.A. (2011) Qualitative and Quantitative Analysis of Rubella IgG antibody among Pregnant Women in Ibadan, Nigeria. Fourteenth Annual Conference on Vaccine Research in Baltimore, Maryland, USA between May 16 and 18, 2011. Abstract number: TG10 (Poster presentation) P.101

     7.      Adewumi M.O., Donbraye E., Sule W.F., Olaniran O., (2012) Hepatitis B surfaceAntigenemia among HIV Cohort and other Hospital Attendees in Southwestern Nigeria. Keystone Symposium titled ‘Frontiers in HIV Pathogenesis, Therapy and Eradication’ Whistler Conference Centre, Whistler, British Columbia, Canada between March 26 and 31, 2012.  Abstract number: X8 139 (Poster presentation)  P.162 

Contact Information

 Phone: 08060226655  Address:  EmailThis email address is being protected from spambots. You need JavaScript enabled to view it.
 FacebookProfile Link  LinkedInProfile Link  TwitterProfile Link
 InstagramProfile Link  YouTubeProfile Link
PinterestProfile Link

Social Links

Get In Touch