Research Gate Profile Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Email Address 1: This email address is being protected from spambots. You need JavaScript enabled to view it. Biography: Jonah ACHEM (B.Sc. M.Sc. Ph.D) Dr Achem is a graduate of Biochemistry from University of Ilorin, Ilorin, Kwara State. He also obtained a Masters degree (M.Sc.) in Biochemistry and a Doctor of Philosophy degree (Ph.D) from University of Ibadan. His research during his doctoral degree programme focused on the influence of Mitochondrial – Mediated Apoptosis by solvent fractions of Daniellia oliveri stem bark, with particular interest on the bioactive agents present in this plant with the aim of developing drugs for the management of diseases where apoptosis is dysregulated including tumors, cancer and neurodegenerative conditions. 1. Ph.D Thesis: Modulation of Mitochondrial – Mediated Apoptosis by Solvent Fractions of Daniellia oliveri (ROLFE) Stem Bark. Solvent fractions of Daniellia oliveri stem bark contains some bioactive compounds that can effectively scavage reactive oxygen species and thus could exhibit anti-cancer, anti-inflammatory, anti-ageing and anti-tumour activity. Daniellia oliveri also promotes bax, cytochrome c and p53 proteins and suppresses bcl-2, thus substantiating the anti-tumour property of this plant by indigenous people. Selected Publications 1. Achem, J., Onyiba, I.C., Akinwole, M.T., Malgwi, J.M., Bolarin, L.O., and Olorunsogo, O.O. (2020). Investigating the Modulatory Effect of Methanol Extract of Daniellia oliveri (ROLFE) Leaves on Mitochondrial Membrane Permeability Transition (MPT) Pore. 4. Adaramoye, O. A., Achem, J., Akintayo, O. O., & Fafunso, M. A. (2007). Hypolipidemic effect of Telfairia occidentalis (fluted pumpkin) in rats fed a cholesterol-rich diet. Journal of medicinal food, 10(2), 330-336. Facebook: Profile Link Profile
Name: Jonah ACHEM
Designation: Lecturer II
Faculty: Basic Medical Sciences
Department: Biochemistry
Phone Number: +2348032987724
Research
2. M.Sc. Dissertation: Hypocholesterolemic Effects of Two Commonly Consumed Tropical Leafy Vegetables; Vernonia amygdalina and Telferia occidentalis in Rats Fed on High Cholesterol Diet. Consumption of Vernonia amygdalina and Telferia occidentalis exhibit
significant health benefits, occurring through the modification of physiologic functions including various atherogenic lipid profiles and antioxidants in hypercholesterolemic rats.
3. B.Sc. Project Report: Effects of Feeding a Flavouring Agent on Phosphatase Activities of Some Rat Tissues. Administration of maggi solution to rats for a period of 28 days led to loss in activities of the phosphatase activity investigated. This loss in activities could be attributed to destruction of the organs (kidney and liver) studied.Publications
International Journal of Biochemistry Research & Review, 29(9): 40-51.
2. Achem, J. Oyebode, O.T. Akinwole, M.T. Bolarin, O. Malgwi , J.M. and Olorunsogo, O.O. (2020). Solvent Fractions of Daniellia oliveri (ROLFE) Stem Bark Modulate Rat Liver Mitochondrial Permeability Transition Pore. Archives of Basic and Applied
Medicine (8) 27 - 34.
3. Salemcity A.J. Awe S. Achem J. Akor, P.O. Abuh, O.V. (2017). Phytochemical Screening, Mineral Content Analysis and Assessment of Antibacterial Activity of Methanol Extract of Newbouldia laevis Leaf. Saudi Journal of Pathology and Microbiology. Vol.2, (6):192-196.
5. Adaramoye, O. A., Akintayo, O., Achem, J., & Fafunso, M. A. (2008). Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol
diet. Vascular health and risk management, 4(1), 235 – 241.Social Media Handle
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Dr. Jonah ACHEM
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