Dr. Isaac A. ADEDARA

Profile

	Name: Isaac A. ADEDARA
	Designation: Senior Lecturer
	Faculty: Basic Medical Sciences
	Department: Biochemistry
	Phone Number: +234 703 2962608
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Biography:

Dr. Isaac Adegboyega Adedara obtained the Bachelor of Science (B.Sc.), Masters of Science (M.Sc.) and Doctor of Philosophy (PhD) in Biochemistry from the University of Ibadan, Ibadan, Nigeria in 2001, 2004 and 2011, respectively. He is a Senior Lecturer in the Department of Biochemistry and the immediate past Sub-Dean (Undergraduate), Faculty of Basic Medical Sciences, University of Ibadan (2018-2022). He was a recipient of the prestigious Indian National Science Academy-Jehangir R.D. Tata (INSA-JRD TATA) and the John D. and Catherine T. MacArthur Foundation Fellowships (USA) during his doctoral research program. He had his postdoctoral trainings at the Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, USA with Sir Mobolaji Bank Anthony Fellowship (UK) in 2012 as well as the Department of Biochemical Toxicology, Federal University of Santa Maria, Santa Maria, Brazil with TWAS-CNPq Postdoctoral Fellowship (Brazil) in 2014-2015. He is a recipient of the prestigious Fellowship “Young Talent with Experience Abroad” from CAPES to participate in the project entitled “Pharmacological and nutritional strategies for health promotion” at the Federal University of Santa Maria, Brazil (2021-2022). Dr. Adedara’s research interests over the years have focused on biochemical and molecular toxicology, cellular oxidative stress mechanisms, antioxidant redox biochemistry and chemoprotective mechanisms of phytochemicals in cellular toxicity and diseases, thus contributing to the understanding of Functional foods, Phytomedicine, Nutraceuticals and Molecular Nutrition. He uses a wide range of contemporary and molecular biology tools including, but not limited to, spectrophotometric enzyme assays, western blotting and enzyme-linked immunosorbent assay in his research which have added to the body of knowledge in biomedical research. Dr. Adedara’s studies have demonstrated novel toxicological mechanisms of Aflatoxin B1, a potent and naturally occurring mycotoxin as well as the efficacies of some bioactive food components (kolaviron, protocatechuic acid, gingerols, gallic acid, resveratrol and curcumin) may abate free radical-mediated toxicity and diseases via antioxidant mechanisms, thus promoting good health in humans. Dr. Adedara teaches Cell Biochemistry, Chemistry and Biochemistry of Macromolecules, Enzymes and Intermediary Metabolism as well as Endoplasmic Reticulum (Xenobiochemistry) to Medical (MBBS/BDS), Laboratory Science, Physiotherapy, Pharmacy, Microbiology, Biochemistry, Human Nutrition and Dietetics students in the undergraduate program.  His involvement in the Postgraduate program includes teaching on the Principles and Regulation of Drug Metabolism, seminar presentations and project supervision. He is a distinguished reviewer and has published over 100 research papers in reputable international peer-reviewed journals. Dr. Adedara is an editorial board member of the Journal of Biochemical and Molecular Toxicology, USA.

Area of Specialization

My research activities are focused mainly on biochemical toxicology with special emphasis on Reproductive toxicology, Neurotoxicology and Environmental toxicology.

Resume

Click here for my Resume

Research

Completed Research

1. Investigation into the roles of quercetin and taurine in neurotoxicity and testicular dysfunction induced by trace metals (fluoride and manganese) in rats.
   
   
2. Mechanistic investigation into the influence of alcohol on colitis and its associated testicular dysfunction in pubertal rats.
   
   
3. Elucidation of the biochemical mechanisms underpinning taurine-mediated chemoprotection against reproductive and renal dysfunction in hypertensive rats.
   
   
4. Mechanistic investigation into the influence of protocatechuic acid on reproductive and neuronal dysfunction diabetic rats.

Publications

Selected Publications

1. Adedara I.A., Souza TP, Canzian J, Olabiyi AA, Borba JV, Biasuz E, Sabadin GR, Gonçalves FL, Costa FV, Schetinger MRC, Farombi EO, Rosemberg DB (2022). Induction of aggression and anxiety-like responses by perfluorooctanoic acid is accompanied by modulation of cholinergic- and purinergic signaling-related parameters in adult zebrafish. Ecotoxicology and Environmental Safety 239, 113635. CLICK HERE
   
   
2. Adedara I.A., Costa FV, Biasuz E, Canzian J, Farombi EO, Rosemberg DB. (2022). Influence of acid-sensing ion channel blocker on behavioral responses in a zebrafish model of acute visceral pain. Behavioural Brain Research 416, 113565. CLICK HERE
   
   
3. Canzian J, Gonçalves FLS, Müller TE, Franscescon F, Santos LW, Adedara I.A., Rosemberg DB. (2022). Zebrafish as a potential non-traditional model organism in translational bipolar disorder research: Genetic and behavioral insights. Neuroscience and Biobehavioral Reviews 136, 104620. CLICK HERE
   
   
4. Sabadin GR, Biasuz E, Canzian J, Adedara I.A., Rosemberg DB. (2022). A novel behavioral paradigm to measure anxiety-like behaviors in zebrafish by the concomitant assessment of geotaxis and scototaxis. Progress in neuropharmacology and biological psychiatry. 118:110579. DOI: 10.1016/j.pnpbp.2022.110579. CLICK HERE
   
   
5. Adedara I.A., Ajayi BO, Afolabi BA, Awogbindin IO, Rocha JBT, Farombi EO. (2021) Toxicological outcome of exposure to psychoactive drugs carbamazepine and diazepam on non-target insect Nauphoeta cinerea. Chemosphere. 264(Pt 1):128449. DOI: 10.1016/j.chemosphere.2020.128449. CLICK HERE
   
   
6. Adedara I.A., Godswill US, Mike MA, Afolabi BA, Amorha CC, Sule J, Rocha JBT, Farombi EO. (2021) Chronic ciprofloxacin and atrazine co-exposure aggravates locomotor and exploratory deficits in non-target detritivore speckled cockroach (Nauphoeta cinerea). Environmental Science and Pollution Research. 28(20):25680-25691. CLCIK HERE
   
   
7. Adedara I.A., Owumi SE, Oyelere AK, Farombi EO. (2021) Neuroprotective role of gallic acid in aflatoxin B1-induced behavioral abnormalities in rats. Journal of Biochemical and Molecular Toxicology. 35(3):e22684. DOI: 10.1002/jbt.22684. CLICK HERE
   
   
8. Adedara I.A., Awogbindin IO, Afolabi BA, Ajayi BO, Rocha JBT, Farombi EO. (2020) Hazardous impact of diclofenac exposure on the behavior and antioxidant defense system in Nauphoeta cinerea. Environmental Pollution 265:115053. DOI: 10.1016/j.envpol.2020.115053. (Impact Factor: 8.071). CLICK HERE
   
   
9. Adedara I.A., Fabunmi AT, Ayenitaju FC, Atanda OE, Adebowale AA, Ajayi BO, Owoeye O, Rocha JBT, Farombi EO (2020) Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats. Neurotoxicology. 76:99-110. CLICK HERE
   
   
10. Owumi SE, Adedara I.A., Farombi EO, Oyelere AK. (2020) Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats. Toxicology. 442:152556. DOI: 10.1016/j.tox.2020.152556. CLICK HERE
    
    
11. Adedara I.A., Awogbindin IO, Owoeye O, Maduako IC, Ajeleti AO, Owumi SE, Patlolla AK, Farombi EO. (2020) Kolaviron via anti-inflammatory and redox regulatory mechanisms abates multi-walled carbon nanotubes-induced neurobehavioral deficits in rats. Psychopharmacology (Berl). 237(4):1027-1040. DOI: 10.1007/s00213-019-05432-8. CLICK HERE
    
    
12. Adedara I.A., Adebowale AA, Atanda OE, Fabunmi AT, Ayenitaju AC, Rocha JBT, Farombi EO. (2019) Selenium abates reproductive dysfunction via attenuation of biometal accumulation, oxido-inflammatory stress and caspase-3 activation in male rats exposed to arsenic. Environmental Pollution 254:113079. DOI: 10.1016/j.envpol.2019.113079. CLICK HERE
    
    
13. Adedara I.A., Abiola MA, Adegbosin AN, Odunewu AA, Farombi EO. (2019) Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats. Chemosphere. 237:124501. DOI: 10.1016/j.chemosphere.2019.124501. CLICK HERE
    
    
14. Adedara I.A., Okpara ES, Busari EO, Omole O, Owumi SE, Farombi EO. (2019) Dietary protocatechuic acid abrogates male reproductive dysfunction in streptozotocin-induced diabetic rats via suppression of oxidative damage, inflammation and caspase-3 activity. European Journal of Pharmacology 849:30-42. CLICK HERE
    
    
15. Ajayi BO, Adedara I.A., Farombi EO. (2019) 6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB/c mice. Chemico-Biological Interactions 307:1-7. CLICK HERE
    
    
16. Adedara I.A., Fasina OB, Ayeni MF, Ajayi OM, Farombi EO. (2019) Protocatechuic acid ameliorates neurobehavioral deficits via suppression of oxidative damage, inflammation, caspase-3 and acetylcholinesterase activities in diabetic rats. Food and Chemical Toxicology 125:170-181. CLICK HERE
    
    
17. Adedara I.A., Owoeye O, Awogbindin IO, Ajayi BO, Rocha JBT, Farombi EO. (2018) Diphenyl diselenide abrogates brain oxidative injury and neurobehavioural deficits associated with pesticide chlorpyrifos exposure in rats. Chemico-Biological Interactions. 296:105-116. CLICK HERE
    
    
18. Adedara I.A., Omole O, Okpara ES, Fasina OB, Ayeni MF, Ajayi OM, Busari EO, Farombi EO. (2018) Impact of prepubertal exposure to dietary protocatechuic acid on the hypothalamic-pituitary-testicular axis in rats. Chemico-Biological Interactions. 290:99-109. CLICK HERE
    
    
19. Adedara I.A., Alake SE, Adeyemo MO, Olajide LO, Ajibade TO, Farombi EO. (2018) Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats. Biomedicine and Pharmacotherapy. 97:181-189. CLICK HERE
    
    
20. Owoeye O, Adedara I.A., Farombi EO. (2018) Pretreatment with taurine prevented brain injury and exploratory behaviour associated with administration of anticancer drug cisplatin in rats. Biomedicine and Pharmacotherapy. 102:375-384. CLICK HERE

Supervision

PREVIOUS STUDENTS

1. Umin-Awaji S Godswill. Chronic ciprofloxacin and atrazine co-exposure aggravates locomotor and exploratory deficits in non-target detritivore speckled cockroach (Nauphoeta cinerea), Year 2021.
   
   
2. Chizoba C. Amorha. Influence of atrazine and diclofenac co-exposure on hypothalamic-pituitary-testicular axis function in rats, Year 2021.
   
   
3. Michael A Abiola. Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats, Year 2019.
   
   
4. Adedayo N. Adegbosin. Neurobehavioural and biochemical responses associated with exposure to binary waterborne mixtures of zinc and nickel in rats, Year 2019.
   
   
5. Opeyemi B Fasina. Protocatechuic acid ameliorates neurobehavioral deficits via suppression of oxidative damage, inflammation, caspase-3 and acetylcholinesterase activities in diabetic rats, Year 2018.
   
   
6. Edozie S. Okpara. Impact of prepubertal exposure to dietary protocatechuic acid on the hypothalamic-pituitary-testicular axis in rats. Year 2018.

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