Dr. Amos O. ABOLAJI

Basic Information

Sarah O. NWOZO

Name: Dr. Amos O. ABOLAJI

Faculty: BASIC MEDICAL SCIENCES

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 Department:Biochemistry

 Designation: Senior Lecturer

Brief Biography:

Resume

NAME: ABOLAJI, Olalekan Amos

POSITION:
Senior Lecturer
Department of Biochemistry
University of Ibadan, Ibadan

AREA OF SPECIALISATION:
Molecular Drug Metabolism and Toxicology

INSTITUTION AND LOCATION

DEGREE

YEAR(s)

FIELD OF STUDY

Obafemi Awolowo University, Ile-Ife, Nigeria

University of Lagos, Lagos, Nigeria

University of Calabar, Calabar, Nigeria

B.Sc.

M.Sc.

Ph.D.

1998

2003

2010

Bachelor of Science

Master of Science

Doctor of Philosophy

SCHOLARSHIPS, FELLOWSHIPS AND PRIZES

DETAILS

YEARS

2018 Africa Oxford Initiative Fellowship (Academic Visitor)

Department of Biochemistry, University of Oxford, UK.

August 2018 - September 2018

SOT/AstraZeneca/SOT Endowment Fund Travel Award

To attend and make presentation at the 2015 Society of Toxicology Annual Meeting, in San Diego, CA

March 22–26, 2015

2012/2013 CNPq-TWAS Postdoctoral Fellowship Award

Award of Postdoctoral Fellowship by the Brazilian National Council for Scientific and Technological Development (CNPq) and TWAS, the Academy of Sciences for the Developing World. To investigate ‘Molecular and Biochemical Toxicity Studies on 4-Vinylcyclohexene and its metabolites in Drosophila melanogaster model’ at the Federal University of Santa Maria, Centre for Natural Sciences, Department of Biochemical Molecular Biology, Biochemical Toxicology Unit, Brazil

April 2013-March 2014

2008/2009 Joint NAM S&T-ICCBS PhD Sandwich Fellowship

Non-Aligned and other Developing Countries Science and Technology Centre, India in conjunction with the International Centre for Chemical and Biological Sciences (ICCBS) University of Karachi, Pakistan.To carry out part of my Ph.D. bench work at the Dr Panjwani Centre for Molecular Medicine and Drug Research, University of Karachi, Pakistan

2008-2009

WHO/TDR Travel Fellowship Award

Fifth MIM Pan-African Malaria Conference Nairobi, Kenya

2-6 November 2009

MEMBERSHIP OF LEARNED SOCIETIES                                                       

·         European Teratology Society

·         American Society of Biochemistry and Molecular Biology

·         Society of Toxicology, USA

·         Medicinal Plants Research, Germany

EMPLOYMENT HISTORY

Adjunct Lecturer: Department of Biochemistry, Adeleke University, Ede, Osun State, Nigeria

2015

Adjunct Lecturer: Landmark University, OmuAran, Kwara State, Nigeria

2016

Visiting Lecturer: University of Oxford, U.K.

February, 2019

PROFESSIONAL

(a)Selected Areas of Teaching

·         Chemistry and Metabolism of Carbohydrates

·         Chemistry and Metabolism of Proteins

·         Comparative Biochemistry

·         Advanced Lipid Biochemistry

·         Biochemistry and Immunology of Parasitic Diseases

·         Biochemistry of Nucleic Acids

·         Biochemical Toxicology

(b)Administrative Experience

     University of Ibadan

·         Postgraduate Departmental Coordinator                                                        2017

·         Assistant B.Sc. Coordinator                                                                            2011-2015

·         Member, Departmental Academic Board                                                        2011-Date

·         Coordinator, MBBS/BDS programme                                                             2015

     Covenant University

·         Member, Convocation Subcommittee in charge of Media.                                                       2010

·         Chairman, Media Subcommittee of International Biotechnology Symposium (IBS)                 2009-2010

·         400 Level students’ Adviser                                                                                                      2009-2010

·         100 Level students’ Adviser                                                                                                      2007-2008

·         Assistant Departmental Examination Officer                                                                             2007-2008

 

Researches

RESEARCH  

Completed Research           

YEAR(S)

RESEARCH NAME

2010 Standardisation of Nigerian Grown Artemisia annua using Reversed Phase High Performance Liquid Chromatography
2010 Reproductive and Biochemical assessment studies on Local Artemisia annua in Wistar rats
2010 Contraceptive potential of Artemisia annua in female rats
2011-2012 Reproductive Toxicity Assessment Studies on artemisinin, artemether-lumefantrine and artesunate-amodiaquine in rats
2012 Reproductive Toxicity Study on 2,5-Hexanedione in rats
2013 Molecular and Biochemical Toxicity Studies on ovotoxicant 4 -Vinylcyclohexene using Drosophila melanogaster as a model
  Toxicological Studies on ovotoxicants 4-Vinylcyclohexene monoepoxide and 4-Vinylcyclohexene diepoxide in Drosophila melanogaster
  Possible chemopreventive effect of diphenyl diselenide on mercuric chloride-induced reproductive toxicity in female Wistar rats
  Reproductive toxicity study on 4-Vinylcyclohexene diepoxide in male and female Wistar rats
  Reproductive toxicity studies on trichloroethyelene in female Wistar rats
  Chemopreventive potential of hesperidin against trichloroethyelene-induced toxicity in Drosophila melanogaster

Ongoing Research          

RESEARCH NAME

Rescue potential of curcumin on Cu2+-induced neurotoxicity in healthy (Wild Type) and Alzheimer`s disease model of Drosophila melanogaster
Rescue role of curcumin in aluminium chloride-induced neurotoxicity in healthy and Alzheimer`s disease D. melanogaster

Dissertation and Thesis        

YEAR(S) RESEARCH NAME
2010 Standardisation, Biochemical and Reproductive Toxicity studies on Local Artemisia annua in Wistar rats

Publications

PUBLICATIONS

Years Authors Title Journals Vol: pages
2018 Farombi E.O., Abolaji A.O.,Adetuyi B., Awosanya O., Fabusoro M. Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats J Basic Clin Physiol Pharmacol doi: 10.1515/jbcpp-2018-0114
2018 Nkpaa K.W., Awogbindin I.O., Amadi B.A., Abolaji A.O., Adedara I.A., Wegwu M.O., Farombi E.O. Ethanol exacerbates manganese-induced neurobehavioral Deficits, striatal oxidative stress, and apoptosis via regulation of p53, Caspase-3, and Bax/Bcl-2 ratio-dependent pathway Biol Trace Elem Res doi: 10.1007/s12011-018-1587-4
2018 Abolaji A.O., Adedara A.O., Adie M.A., Vicente-Crespo M., Farombi E.O. Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster Biochemical and Biophysical Research Communications 503: 2, 1042-1048
2018 Farombi EO, Abolaji AO,Farombi TH, Oropo AS, Owoje OA, Awunah MT. Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone-induced toxicity in Drosophila melanogaster Pestic Biochem Physiol 145: 39 ? 45
2018 Kamdem JP, Roos DH, Sanmi AA, Calabró L, Abolaji AO, de Oliveira CS, Barros LM, Duarte AE, Barbosa NV, Souza DO, Rocha JBT Productivity of CNPq Researchers from Different Fields in Biomedical Sciences: The Need for Objective Bibliometric Parameters-A Report from Brazil Sci Eng Ethics doi: 10.1007/s11948-018-0025-5
2018 Akinyemi AJ, Oboh G, Ogunsuyi O, Abolaji AO,Udofia A. Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model. Metab Brain Dis 33: 2, 369 ? 375
2018 Adebayo O.A., Adesanoye O.A., Abolaji, A.O., Kehinde, A.O., Adaramoye, O.A. Administration of first line anti-tuberculosis drugs induces ovarian and uterine oxidative stress and disruption of endocrine balance in rats J Basic Clin Physiol Pharmacol 29: 2, 131?140
2017 Abolaji AO, Babalola OV, Adegoke AK, Farombi EO. Hesperidin, a citrus bioflavonoid, alleviates trichloroethylene-induced oxidative stress in Drosophila melanogaster Environ Toxicol Pharmacol. 55:202?207
2017 Abolaji AO, Ojo M, Afolabi TT, Arowoogun MD, Nwawolor D, Farombi EO. Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats Chem Biol Interact 270: 15?23
2017 Abolaji AO, Olaiya CO, Oluwadahunsi OJ, Farombi EO. Dietary consumption of monosodium L-glutamate induces adaptive response and reduction in the life span of Drosophila melanogaster Cell Biochem Funct 35: 3, 64 - 170
2017 Adedara I.A., Abolaji A.O.,Idris U.F., Olabiyi B.F., Onibiyo E.M., Ojuade T.D., Farombi E.O. Neuroprotective influence of taurine on sodium fluoride-induced biochemical and behavioral deficits in rats Chemico-Biological Interactions 261: 1 - 10
2017 Adedara I.A., Abolaji A.O.,Awogbindin I.O., Farombi E.O. Suppression of the brain-pituitary-testicular axis function following acute arsenic and manganese co-exposure and withdrawal in rats Journal of Trace Elements in Medicine and Biology 39: 21 - 29
2017 Abolaji A.O., Awogbindin I.O., Adedara I.A., Farombi E.O. Insecticide chlorpyrifos and fungicide carbendazim, common food contaminants mixture, induces hepatic, renal, and splenic oxidative damage in female rats Human and Experimental Toxicology 36: 5, 483 - 493
2017 Adedara I.A., Abolaji A.O.,Ladipo E.O., Fatunmibi O.J., Abajingin A.O., Farombi E.O. 4-Vinylcyclohexene diepoxide disrupts sperm characteristics, endocrine balance and redox status in the testes and epididymis of rats Redox Report 22: 6, 388 - 398
2016 Abolaji A.O., Adedara I.A., Abajingin A.O., Fatunmibi O.J., Ladipo E.O., Farombi E.O. Evidence of oxidative damage and reproductive dysfunction accompanying 4-vinylcyclohexene diepoxide exposure in female Wistar rats Reproductive Toxicology 66: 10 - 19
2016 Abolaji A.O., Toloyai P.E., Odeley T.D., Akinduro S., Rocha J.B., Farombi E.O. Hepatic and renal toxicological evaluations of an industrial ovotoxic chemical, 4-vinylcyclohexene diepoxide, in both sexes of Wistar rats Environmental Toxicology and Pharmacology 45: 28 - 40
2016 Abolaji A.O., Adesanoye O.A., Awogbindin I., Farombi E.O. Endocrine disruption and oxidative stress implications of artemether-lumefantrine combination therapy in the ovary and uterus of rats Human Experimental Toxicology 35: 11, 1173 - 1182
2016 Kamdem J.P., Abolaji A.O.,Elekofehinti O.O., Omotuyi I.O., Ibrahim M., Waseem Hassan, Barbosa N.V., Souza D.O., Rocha J.B Therapeutic potential of plant extracts and phytochemicals against brain ischemia-reperfusion injury: A Review The Natural Products Journal 6: 4, 250 - 284
2016 Kamdem J.P., Abolaji A.O.,Roos D.H., Calabró L., Barbosa N.V., Souza D.O., Rocha J.B Scientific Performance of Brazilian Researchers in Pharmacology with grants from CNPq: A comparative study within the Brazilian categories Anais Da Academia Brasileira De Ciencias 88: 3, 1735 - 1742
2016 Adedara I.A., Abolaji A.O.,Odion B.E., Omoloja A.A., Okwudi I.J., Farombi E.O. Redox status of the testes and sperm of rats following exposure to 2,5-hexanedione. Redox Report 21:6, 239 - 247
2016 Adedara I.A., Abolaji A.O.,Rocha J.B.T., Farombi E.O Diphenyl diselenide protects against mortality, locomotor deficits and oxidative stress in Drosophila melanogaster model of manganese-induced neurotoxicity Neurochemical Research 41: 6, 1430 - 1438
2015 Abolaji A.O., Kamdem J.P., Lugokenski T.H., Farombi E.O., Souza D.O., Loreto E.L., Rocha J.B Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster Redox Biology U.S.A. 5: 328 - 339
2015 Waczuk E.P., Kamdem J.P., Abolaji A.O., Meinerz D.F, Bueno D.C., Nascimento T.K., Dorow T.S., Boligon A.A., Athayde M.L., Rocha J.B., Avila D.S Euphorbia tirucalli aqueous extract induces cytotoxicity, genotoxicity and changes in antioxidant gene expression in human leukocytes Toxicology Research U.K. 4: 739 - 748
2014 Abolaji,A.O., Kamdem, J.P., Lugokenski, T.H., Nascimento, T.K., Waczuk, E.P., Farombi, E.O., Loreto, E.L., Rocha J.B.T. Involvement of oxidative stress in 4-vinylcyclohexene-induced toxicity in Drosophila melanogaster. Free Radical Biology and Medicine, U.S.A. 71: 99 - 108
2014 Abolaji A.O., Eteng M.U., Ebong P.E., Dar A., Farombi E.O., Choudhary M.I. Artemisia annua as a possible contraceptive agent: a clue from mammalian rat model Natural Product Research UK 24: 2342 - 2346
2014 Farombi, E.O., Adedara, I.A., Abolaji, A.O., Anamelechi, J.P., Sangodele, J.O. Sperm characteristics, antioxidant status and hormonal profile in rats treated with artemisinin Andrologia. Germany 46: 8, 893 - 901
2014 Filho, V.M., Waczuk, P.W., Kamdem, J.P., Abolaji, A.O.,Lacerda, S.R., Costa, J.G., Menezes, I.R., Boligon, A.A., Athayde, M.L., Rocha, J.B., Thais, P. Phytochemical constituents, antioxidant activity, cytotoxicity and osmotic fragility effects of Caju (Anacardium microcarpum) Industrial Crops and Products. Netherlands 55: 280 - 288
2014 Farombi, E.O., Abolaji, A.O., Adedara, I.A., Soladogun, A., Salau, V., Oguaka, M. Oxidative stress and changes in antioxidative defence system in erythrocytes of female rats exposed to 2, 5-Hexanedione. Archives of Basic and Applied Medicine. Nigeria 2: 29 - 33
2014 Farombi, E.O., Abolaji, A.O., Adedara, I.A., Maduako, I., Omodanisi, I. Artemisinin induces hormonal imbalance and oxidative damage in the erythrocytes and uterus but not in the ovary of rats. Human and Experimental Toxicology. UK 34: 1, 83 - 92
2014 Adedara I.A., Abolaji A.O., Odion B., Okwudi I., Omoloja A., Farombi E.O. Impairment of hepatic and renal functions by 2,5-hexanedione is accompanied by oxidative stress in rats Journal of Toxicology doi: 10.1155/2014/239240
2014 Ogunbolude Y., Ibrahim M., Elekofehinti O.O., Adeniran A., Abolaji A.O., Rocha J.B.T., Kamdem J.P. Effects of Tapinanthus globiferus and Zanthoxylum zanthoxyloides extracts on human leukocytes in vitro Journal of Intercultural Ethnopharmacology. Turkey 3: 4, 167 - 172
2013 Abolaji, A.O., Eteng, M.U., Omonua, O., Adenrele, Y. Influence of co-administration of artemether and lumefantrine on selected plasma biochemical and erythrocyte oxidative stress indices in female Wistar rats. Human and Experimental Toxicology. UK 32: 2, 206 - 215
2013 Abolaji, A.O, Eteng, U.M., Ebong, P.E., Brisibe, E.A., Dar, A., Kabir N., Choudhary M.I. A safety assessment of the antimalarial herb Artemisia annua during pregnancy in Wistar rats Phytotherapy Research 27: 5, 647 - 654
2013 Eteng, M.U., Abolaji, A.O., Ebong, P.E., Brisibe, E.A., Dar A., Kabir N., Choudhary M.I. Biochemical and haematological evaluation of repeated doseexposure of male Wistar rats to an ethanolic extract of Artemisiaannua Phytotherapy Research. UK 27: 4, 602 - 609
2013 Abolaji, A.O., Kamdem, J.P., Farombi, E.O., Rocha, J.B.T. Drosophila melanogaster as a promising model organism in toxicological studies. A mini review Archives of Basic and Applied Medicine. Nigeria 1: 33 - 38
2013 Abolaji, A.O., Osedeme, F., Olusemire, O. Artesunate-amodiaquine combination therapy in the absence of malarial parasite infection induces oxidative damage in female rats. Cell Biochemistry and Function. UK 32: 303 - 308
2012 Olasehinde, G.I., Yah, C.S., Singh, R, Ojurongbe, O. O., Ajayi, A.A., Valecha, N, Abolaji, A.O., Adebiyi, M.O., Adeyeba, O.A. Genetic diversity of Plasmodium falciparum field Isolates from South Western Nigeria African Health Sciences. Uganda 12: 3, 355 - 361
2011 Adebayo, A.H., Abolaji, A.O., Kela R., Oluremi, S.O., Owolabi, O.O., Ogungbe, O.A. Hepatoprotective activity of Chrysophyllum albidum against carbon tetrachloride-induced hepatic damage in rats. Canadian Journal of Pure and Applied Sciences. Canada 5: 3, 1597 - 1602
2011 Adebayo, A.H, Abolaji, A.O., Kela, S. Ayepola, O.O., Olorunfemi, T., Taiwo, O.S. Antioxidant activities of the leaves of Chrysophyllum albidum G. Pakistan Journal of Pharmaceutical Sciences. Pakistan 24: 4, 545 - 551
2010 Eteng, M.U., Ekwe, A.O., Abolaji, A.O., Eyong, E.U., Ibekwe, H.A., Osuchukwu, N.C. Biochemical and haematological changes in pregnant malaria patients and pregnant non-malaria women Scientific Research and Essays. Nigeria 5: 9, 1009 - 1013
2010 Abolaji, A.O., Eteng, M.U., Ebong, P.E., Brisibi, A., Shakil, A., Erum, S., Choudhary, M.I Standardisation of Artemisia annua using Reversed Phase High Performance Liquid Chromatography (RP-HPLC) Pharmacognosy Journal. India 2: 7, 143 - 147
2010 Adebayo, A.H., Abolaji, A.O., Opata, T.K., Adegbenro, I.K. Effects of ethanolic leaves extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wistar rats African Journal of Biotechnology. Kenya 9: 14, 2145 -- 2150
         
2009 Eteng, M.U., Ibekwe, H.A., Abolaji, A.O., Okoi, A. I., Onwuka, F. C., Osuchukwu, N.C Effect of Rauwolfia vomitoria Afzel (Apocynaceae) extract on serum amino transferase and alkaline phosphatase activities and selected indices of liver and kidney functions African Journal of Biotechnology. Kenya 8: 18, 4604 - 4607
2008 Eteng, M.U., Ukpanukpong, R.U., Abolaji, A.O, Eyong, E.U., Egbung, E. Biochemical and histological alteration and effect of perfloxacin on Wistar rats reproductive function Australian Journal of Basic and Applied Sciences. Jordan 2: 3, 475 - 480
2008 Eteng, M.U., Onwuka, F.C., Umoh, I.B., Abolaji, A.O. Trans-generational effects of cadmium toxicity on gonadal steroid levels and reproductive outcome of Wistar rats Journal of Applied Sciences Research. India 4: 7, 925 - 928
2008 Eteng, M.U., Bassey, B.J., Atangwho, I.J., Egbung, G.E., Eyong, E.U., Ebong, P.E., Abolaji, A.O. Biochemical indices of macrovascular complication in diabetic rat model: Compared effects of Vernonia amygdalina, Cathanrantus roseus and Chlorpropamide Asian Journal of Biochemistry. India 3: 4, 228 - 234
2007 Abolaji, A.O., Adebayo, A.H., Odesanmi, O.S. Effects of ethanolic fruit extract of Parinari polyandra (Rosaceae) on serum lipid profile and some electrolytes in pregnant rabbits Research Journal of Medicinal Plant. Kenya 1: 4, 121 - 127
2007 Abolaji, A.O., Adebayo, A.H., Odesanmi, O.S. Nutritional qualities of three medicinal plant parts (Xylopia aethiopica, Blighia sapida and Parinari polyandra) commonly used by pregnant women in the western part of Nigeria Pakistan Journal of Nutrition 6: 6, 665 - 668

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