Professor Amos O. ABOLAJI

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 Dr. Amos Olalekan ABOLAJI

Name:  Amos O. ABOLAJI

Designation: Professor
Faculty: Basic Medical Sciences
Department: Biochemistry

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Brief Biography:

Professor Amos Olalekan Abolaji is a Professor of Biochemistry in the Molecular Drug Metabolism and Toxicology Unit, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan. He earned his B.Sc. in Biochemistry from Obafemi Awolowo University, Ile-Ife (1998), his M.Sc. from the University of Lagos (2003) and his Ph.D. from the University of Calabar (2010). He is the current Deputy Provost (Administration), Postgraduate College, University of Ibadan (2024-2026)

His research lies at the interface of molecular toxicology, oxidative stress biology and disease modelling. Working with both rodent and Drosophila melanogaster models, he has led and co-led projects that elucidate the redox and molecular mechanisms through which environmental contaminants exert their effects, and that examine how phytochemicals can confer protection against them. Over the course of his career, he has supervised more than 140 undergraduate, master’s and doctoral students, and currently supervises or co-supervises six Ph.D. candidates at the University of Ibadan; a record that reflects his ability to build, mentor and sustain a productive research team.

In 2014, following postdoctoral training at the Federal University of Santa Maria, Brazil, Professor Abolaji established the first Drosophila melanogaster laboratory in the Department of Biochemistry at the College of Medicine, University of Ibadan (DROSLABUI). Now well equipped, the laboratory maintains active collaborations with scientists in the United Kingdom, the United States, Germany, Spain and Brazil, and has trained staff and students from 21 Nigerian institutions in the use of Drosophila for experimental medicine.

Since 2019 he has served as a Visiting Lecturer on the M.Sc. in International Health and Tropical Medicine at the Nuffield Department of Medicine, University of Oxford. The role followed a 2018 Africa-Oxford Visiting Fellowship in the Department of Biochemistry (Ilan Davis’ laboratory), where he received further training in Drosophila imaging.

Professor Abolaji has received numerous awards and fellowships, among them are the WHO/TDR Travel Fellowship to the Fifth MIM Pan-African Malaria Conference in Nairobi (2009), the CNPq-TWAS Postdoctoral Fellowship at the Federal University of Santa Maria, Brazil (2013–2014), the SOT/AstraZeneca Endowment Fund Travel Award (2015) and the Africa-Oxford Visiting Fellow Award (2018). His research has been supported by a CRP-ICGEB grant (2018), Cambridge-Africa ALBORADA Research Grants (2016, 2018 and 2026) and an International Society for Neurochemistry CAEN grant (2016). He is a member of the Society of Toxicology, the Society for Redox Biology and Medicine, the European Teratology Society, the Genetics Society of America and the Neuroscience Society of Nigeria. He has authored more than 90 peer-reviewed publications and, according to Google Scholar, holds an h-index of 32, more than 3,600 citations and an i10-index of 67 (July 2026). His work is underpinned by international collaborations spanning Africa, Brazil, Europe, the United Kingdom and the United States.

Alongside his university appointment, Professor Abolaji serves, on a non-salaried basis, as Team Lead of the Drosophila Research and Training Centre (DRTC LTD/GTE; Company Reg. No. 1783524; www.drosophilartc.org). A non-profit institute, the DRTC advances the use of Drosophila melanogaster as a cost-effective, genetically tractable model organism for biomedical research and training across sub-Saharan Africa. It works closely with DROSLABUI, supporting postgraduate students with consumables, training and access to facilities, and has donated laboratory consumables and basic equipment to research groups in institutions across Nigeria.


Research

Completed Projects and Contributions

1. Establishing Drosophila melanogaster as a Model for Toxicology and Biomedical Research

This foundational strand made the case for the fruit fly as a fast, ethical and genetically tractable alternative to rodents in toxicology and disease research. Through a widely cited mini-review and a textbook chapter, the work laid out how Drosophila conserves the core biology of oxidative stress, detoxification and neurodegeneration relevant to humans, and provided a practical framework that has since been adopted by many laboratories across Africa and beyond. Its contribution was to lower the barrier to entry for invertebrate toxicology and to legitimise the model for the disease-oriented studies that follow in the groups below.

Publications in this project:

[49] Abolaji, A.O., Kamdem, J.P., Igharo, O.G. and Adedara A. (2020). Experimental models III: Biology and use of Drosophila melanogaster as a model in biomedical research. In: Anetor, J.I. and Igharo, O.G. (Eds.) The Biomedical Explorer: A Textbook of Biomedical Research Innovation. Lagos: UNILAG Press and Bookshop LTD. 127144pp. ISBN 978-978-57646-2-6. (Nigeria).

[84] Abolaji, A.O., Kamdem, J.P., Farombi, E.O., Rocha, J.B.T. (2013): Drosophila melanogaster as a promising model organism in toxicological studies. A mini review. Archives of Basic and Applied Medicine Vol. 1, 33-38. (Nigeria).

2. Neurodegeneration and Parkinson's Disease: Neuroprotection by Dietary Phytochemicals

A sustained programme using chemical (MPTP, rotenone) and genetic (α-synuclein, parkin) Drosophila models of Parkinson's disease to test whether dietary polyphenols and carotenoids can slow neurodegeneration. The studies showed, with converging behavioural, biochemical and mitochondrial evidence, that compounds such as resveratrol, hesperetin/hesperidin, kaempferol, naringenin, ellagic acid and trans-astaxanthin restore motor function, curb oxidative damage and protect mitochondria. Coupled increasingly with computational (molecular docking) analyses, this body of work advanced the mechanistic rationale for nutrition-based neuroprotection and identified specific, affordable natural candidates worthy of translational follow-up.

Publications in this project:

[11] Abolaji AO, Adedara AO, Madu JC, Owalude OT, Ogunyemi OM, Omoboyowa DA, Omage FB, Whitworth AJ, Aschner M. Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson's disease. Sci Rep. 2025 May 22;15(1):17769. doi: 10.1038/s41598-025-00698-9. PMID: 40404673; PMCID: PMC12098997.

[12] Okonta C, Ogunyemi OM, Olabuntu B, Abolaji AO. Ameliorative role of naringenin in MPTP- induced Parkinsonism: Insights from Drosophila melanogaster experimental model combined with computational biology. Toxicol Rep. 2025 Mar 20;14:102004. doi: 10.1016/j.toxrep.2025.102004. PMID: 40213420; PMCID: PMC11982306.

[19] Adedara AO, Bressan GN, Dos Santos MM, Fachinetto R, Abolaji AO, Barbosa NV. (2024). Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster. Neurotoxicology.101:117-127. doi: 10.1016/j.neuro.2024.02.006.

[22] Omotayo T, Otenaike TA, Adedara AO, Adeyemi OE, Jonhnson TO, Abolaji AO. (2023). Biological interactions and attenuation of MPTP-induced toxicity in Drosophila melanogaster by Trans-astaxanthin. Neurosci Res. S0168-0102(23)00110-4. doi: 10.1016/j.neures.2023.06.005.

[23] Adedara AO, Otenaike TA, Farodoye OM, Abolaji AO. (2023). Ellagic acid mitigates rotenone-induced damage via modulating mitochondria function in Drosophila melanogaster. J Biochem Mol Toxicol. 37(6):e23332. doi: 10.1002/jbt.23332.

[24] Adedara AO, Wildner G, Loreto JS, Dos Santos MM, Abolaji AO, Barbosa NV. (2023). Kaempferol counteracts toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in D. melanogaster: An implication of its mitoprotective activity. Neurotoxicology. 95:23-34. doi: 10.1016/j.neuro.2022.12.008.

[25] Adedara AO, Otenaike TA, Olabiyi AA, Adedara IA, Abolaji AO. (2023). Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron. Metab Brain Dis. 38(1):349-360. doi: 10.1007/s11011-022-01104-3.

[29] Akinade TC, Babatunde OO, Adedara AO, Adeyemi OE, Otenaike TA, Ashaolu OP, Johnson TO, Terriente-Felix A, Whitworth AJ, Abolaji AO. (2022). Protective capacity of carotenoid trans-astaxanthin in rotenone-induced toxicity in Drosophila melanogaster. Scientific Reports 12(1):4594. doi: 10.1038/s41598-022-08409-4.

[30] Adedara AO, Babalola AD, Stephano F, Awogbindin IO, Olopade JO, Rocha JBT, Whitworth AJ, Abolaji AO. (2022). An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster. Scientific Reports 12(1):3922. doi: 10.1038/s41598-022-07909-7.

[51] Abolaji A.O., Adedara A.O., Adie M.A., Vicente-Crespo M., Farombi E.O. (2018). Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster. Biochemical and Biophysical Research Communications Vol. 503 No. 2,1042-1048.

[53] Farombi EO, Abolaji AO, Farombi TH, Oropo AS, Owoje OA, Awunah MT. (2018). Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone-induced toxicity in Drosophila melanogaster. Pesticide Biochemistry and Physiology. Vol. 145, 39-45.

[55] Akinyemi AJ, Oboh G, Ogunsuyi O, Abolaji AO, Udofia A. (2018). Curcuminsupplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model. Metabolic Brain Disease. Vol. 33 No. 2, 369-375.

3. Heavy-Metal and Metalloid Toxicity and Metal-Chelation Therapeutics

One of the group's largest and most cohesive programmes, mapping how copper, iron, aluminium, cadmium, arsenic, manganese, mercury and chromium disrupt redox balance, mitochondrial function and survival, and how these harms can be countered. It spans mechanistic Drosophila studies, tests of chelators (D-penicillamine) and protective phytochemicals (curcumin, hesperidin, kolaviron, Vitellaria and Ficus extracts), and influential reviews on biometal chelation in Alzheimer's disease and on lessons from the fly for non-essential metals. The collective contribution is a detailed, model-validated picture of metal neurotoxicity together with practical, dietary and pharmacological strategies to mitigate environmental and occupational metal exposure.

Publications in this project:

[8] Otenaike. T. A., Farodoye, O. M., Olaniyan, H., Teibo, J. O., Faleke, H. A., Akinola, I. A., Molik, Z. A., Aschner, M., Abolaji, A. O. (2026). Neurotoxicity of heavy metals across the lifespan: The beneficial role of nutrition from fetus to the elderly. In Advances in Neurotoxicology, ISSN 2468-7480. Elsevier. https://doi.org/10.1016/bs.ant.2026.03.003

[13] Akano JM, Molik ZA, Abolaji AO, Ogbole OO. Mitigating aluminum chloride-induced toxicity in Drosophila melanogaster with peptide fractions from Euphorbia species. Drug Chem Toxicol. 2025 May;48(3):687-696. doi: 10.1080/01480545.2024.2421916. Epub 2024 Nov 5. PMID: 39501706.

[14] Ashaolu OP, Odukanmi OA, Salami AT, Abolaji AO, Olaleye SB. Kolaviron: a Bioflavonoid from Seed Extract of Garcinia kola Attenuates Chromium (VI)-Induced Gut Dysfunction and Oxidative Damage in Drosophila melanogaster. Biol Trace Elem Res. 2025 Jun;203(6):3366-3375. doi: 10.1007/s12011-024-04414-y. Epub 2024 Oct 19. PMID: 39425879.

[16] Asejeje FO, Asejeje GI, Ogunro OB, Adedara AO, Abolaji AO (2024). Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity. BMC Pharmacol Toxicol. 25(1):70. doi: 10.1186/s40360-024-00792-0. PMID: 39334451; PMCID: PMC11438368.

[21] Oyibo A, Abolaji AO, Omoboyowa DA, Odunola OA. (2023). Vitellaria paradoxa Inhibits Arsenic-induced Toxicity in Drosophila melanogaster Via the Augmentation of Antioxidant System. Toxicology. 153590. doi: 10.1016/j.tox.2023.153590. Epub ahead of print.

[26] Asejeje FO, Ogunro OB, Asejeje GI, Adewumi OS, Abolaji AO. (2023). An assessment of the ameliorative role of hesperidin in Drosophila melanogaster model of cadmium chloride-induced toxicity. Comp Biochem Physiol C Toxicol Pharmacol. 263:109500. doi: 10.1016/j.cbpc.2022.109500.

[28] Fasae, K.D., Adeyemi, O., Faleke, H.O., Abolaji, A.O. (2023). Neurotoxicity of iron (Fe) in Drosophila and the protective roles of natural products. Advances in Neurotoxicology, 2023, 9, pp. 321-342

[31] Fasae KD, Abolaji AO. (2022). Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster. Current Opinion Insect in Science 51:100900. doi: 10.1016/j.cois.2022.100900. Epub 2022 Mar 7.

[34] Oyebode OT, Abolaji AO, Faleke HO, Olorunsogo OO. (2021). Methanol fraction of Ficus mucoso (welw) prevents iron-induced oxidative damage and alters mitochondrial dysfunction in Drosophila melanogaster. Drug and Chemical Toxicology 30:1-9. doi: 10.1080/01480545.2021.1979997.

[35] Oyibo A, Abolaji AO, Odunola OA. (2021). Carcinogen sodium arsenite disrupts antioxidant and redo homeostasis in Drosophila melanogaster. Journal of Basic Clinical Physiology and Pharmacology doi: 10.1515/jbcpp-2020-0235.

[36] Fasae KD, Abolaji AO, Faloye TR, Odunsi AY, Oyetayo BO, Enya JI, Rotimi JA, Akinyemi RO, Whitworth AJ, Aschner M. (2021). Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives. Journal of Trace Element in Medicine and Biology. 67:126779. doi: 10.1016/j.jtemb.2021.126779.

[41] Ibraheem, O., Bankole, D., Adedara, A., Abolaji A.O., Fatoki T.H., Ajayi, J.M., Eze, C.T. (2021). Methanolic leaves and arils extracts of ackee (Blighia sapida) plant ameliorate mercuric chloride-induced oxidative stress in Drosophila melanogaster Biointerface Research in Applied Chemistry. 11(1), pp. 7528-7542

[42] Abolaji AO, Fasae KD, Iwezor CE, Farombi EO. (2020). D-Penicillamine prolongs survival and lessens copper-induced toxicity in Drosophila melanogaster. Toxicology Research (Camb). 9(4):346-352. doi: 10.1093/toxres/tfaa032.

[45] Abolaji AO, Fasae KD, Iwezor CE, Aschner M, Farombi EO. (2020). Curcumin attenuates copper-induced oxidative stress and neurotoxicity in Drosophila melanogaster. Toxicology Reports. 7:261-268. doi: 10.1016/j.toxrep.2020.01.015.

[46] Oyetayo, B.O., Abolaji, A.O., Fasae, K.D., Aderibigbe, A. (2020). Ameliorative role of diets fortified with Curcumin in a Drosophila melanogaster model of aluminum chloride-induced neurotoxicity. Journal of Functional Foods, 2020, 71, 104035

[70] Adedara I.A., Abolaji A.O., Rocha J.B.T., Farombi E.O. (2016). Diphenyl diselenide protects against mortality, locomotor deficits and oxidative stress in Drosophila melanogaster model of manganese-induced neurotoxicity. Neurochemical Research Vol. 41 No. 6, 1430-1438.

4. Nicotine, E-Cigarette and Vaping Neurotoxicology

A focused, emerging line of work dissecting how nicotine and e-cigarette/vape exposure impair memory and behaviour, pinpointing the roles of α7 and β2 nicotinic acetylcholine receptor subunits in sensory valence, cellular stress and associative learning. By showing that nicotine and vaping share a common toxicological profile, these studies contribute timely mechanistic evidence to the public-health debate over vaping safety and establish Drosophila as a rapid screen for the neurobehavioural risks of inhaled nicotine products.

Publications in this project:

[4] Otenaike, T.A., Farodoye, O.M., Rocha, J.B.T., Abolaji, A.O., Loreto, E.L.S. (2026). Mechanisms of nicotine toxicity and addiction-like behavior in Drosophila melanogaster: The role of α7 & β2 nicotinic acetylcholine receptor subunits in sensory valence and cellular stress. Neurotoxicology 115:103499. doi: 10.1016/j.neuro.2026.103499.

[6] Otenaike TA, Farodoye O, Silva KK, Abolaji AO (2026). Loreto ELS. E-cigarette exposure impairs associative memory: role of α7 and β2 nicotinic acetylcholine receptors. J Neurogenet. 23:1-18. doi: 10.1080/01677063.2026.2613797.

[10] Otenaike TA, Farodoye OM, de Silva MM, Loreto JS, Adedara AO, Dos Santos MM, de Prestes AS, Barbosa NV, da Rocha JBT, Lobo LE, Wagner R, Abolaji AO, Loreto ELS (2024). Nicotine and Vape: Drugs of the Same Profile Flock Together. J Biochem Mol Toxicol. 38(12):e70075. doi: 10.1002/jbt.70075.

5. Environmental, Industrial and Food-Additive Chemical Toxicity

This programme characterised the toxicity of chemicals people encounter daily - acrylamide, bisphenol A, sodium benzoate, monosodium glutamate, trichloroethylene, fluoride, benzo[a]pyrene and other contaminants - and tested protective interventions. Highlights include RNA-sequencing that revealed transcriptomic and retrotransposon changes underlying acrylamide toxicity, and demonstrations that luteolin and hesperidin can offset additive- and solvent-induced damage. The work supplies regulators and consumers with mechanistic evidence on the safety of common additives and industrial chemicals, and with candidate dietary countermeasures.

Publications in this project:

[3] Madu, J.C., Abolaji, A.O., Adaramoye, O.A. (2026). Co-Exposure of N-Methyl-N-Nitrosourea and Benzo[A]Pyrene Elicits Toxicity in Drosophila Melanogaster. Journal of Biochemical and Molecular Toxicology 40(6):e70915. doi: 10.1002/jbt.70915.

[5] Farodoye OM, Otenaike TA, Mombach DM, Silva MM, Abolaji AO, Loreto ELDS. Diving Deeper into Mechanisms of Acrylamide-Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster. Environ Toxicol. 2026 Feb 23. doi: 10.1002/tox.70054. Epub ahead of print. PMID: 41725541.

[7] Oyibo A., Adedara-Balogun A., Ojo O.B., Molik Z.A., Otenaike T.A., Aschner M., Abolaji A.O. (2026). Harnessing Drosophila melanogaster to unravel micro/nanoplastics-induced neurotoxicity and protective mechanisms: A new frontier in environmental neurotoxicology. Advances in Neurotoxicology, Academic Press, 2026, ISSN 2468-7480, https://doi.org/10.1016/bs.ant.2026.03.007.

[17] Farodoye OM, Otenaike TA, Loreto JS, Adedara AO, Silva MM, Barbosa NV, Rocha JBTD, Abolaji AO, Loreto ELS. (2024) Evidence of acrylamide-induced behavioral deficit, mitochondrial dysfunction and cell death in Drosophila melanogaster. Comp Biochem Physiol C Toxicol Pharmacol. 284:109971. doi: 10.1016/j.cbpc.2024.109971. Epub ahead of print. PMID: 38972620.

[20] Asejeje FO, Alade TF, Oyibo A, Abolaji AO. (2024). Toxicological assessment of sodium benzoate in Drosophila melanogaster. J Biochem Mol Toxicol. 38(1):e23586. doi: 10.1002/jbt.23586. Epub 2023 Nov 20. PMID: 37986221.

[37] Johnson TO, Abolaji AO, Omale S, Longdet IY, Kutshik RJ, Oyetayo BO, Adegboyega AE, Sagay A. (2021). Benzo[a]pyrene and Benzo[a]pyrene-7,8dihydrodiol-9,10-epoxide induced locomotor and reproductive senescence and altered biochemical parameters of oxidative damage in Canton-S Drosophila melanogaster. Toxicology Reports. 8:571-580. doi: 10.1016/j.toxrep.2021.03.001.

[43] Adesanoye OA, Abolaji AO, Faloye TR, Olaoye HO, Adedara AO. (2020). Luteolin Supplemented diets ameliorates Bisphenol A-Induced toxicity in Drosophila melanogaster. Food and Chemical Toxicology. 142:111478. doi: 10.1016/j.fct.2020.111478.

[50] Abolaji A.O., Ajala V.O., Adigun J.O., Adedara I.I., Kinyi H.W., Farombi E.O. (2019). Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity in Drosophila melanogaster. Exp Biol Med (Maywood). doi: 10.1177/1535370219890334.

[57] Abolaji AO, Babalola OV, Adegoke AK, Farombi EO. (2017). Hesperidin, a citrus bioflavonoid, alleviates trichloroethylene-induced oxidative stress in Drosophila melanogaster. Environmental Toxicology and Pharmacology. Vol 55, 202-207.

[59] Abolaji AO, Olaiya CO, Oluwadahunsi OJ, Farombi EO. (2017). Dietary consumption of monosodium L-glutamate induces adaptive response and reduction in the life span of Drosophila melanogaster. Cell Biochemistry Function. Vol 35 No. 3, 164-170.

6. Reproductive and Endocrine Toxicology: 4-Vinylcyclohexene, Industrial Solvents and Drug Safety

Beginning with detailed rodent and fly studies of the ovotoxicant 4-vinylcyclohexene and its epoxides, this programme documented how industrial chemicals (4-VCH/4-VCD, 2,5-hexanedione, cadmium) and certain drugs damage the ovary, uterus, testis and sperm, disrupt endocrine balance and provoke oxidative stress. It established dose-response and redox mechanisms of ovarian and testicular toxicity and evaluated protective agents such as hesperidin. The contribution is a rigorous evidence base on chemical threats to reproductive health, spanning both mammalian and invertebrate systems.

Publications in this project:

[40] Balogun, O., Abolaji, A.O., Adedara, A.O., Akinsanmi, A.O., Alemika, T.E. (2021). Ameliorative role of Plectranthus esculentus on 4-vinylcyclohexene monoepoxideinduced oxidative stress in Drosophila melanogaster. Biointerface Research in Applied Chemistry. 11(2), pp. 9432-9442

[44] Abolaji AO, Omozokpia MU, Oluwamuyide OJ, Akintola TE, Farombi EO. (2020). Rescue role of hesperidin in 4-vinylcyclohexene diepoxide-induced toxicity in the brain, ovary and uterus of Wistar rats. Journal of Basic Clinical Physiology and Pharmacology. 31(2): doi: 10.1515/jbcpp-2018-0115.

[56] Adebayo O.A., Adesanoye O.A., Abolaji, A.O., Kehinde, A.O., Adaramoye, O.A. (2018). Administration of first line anti-tuberculosis drugs induces ovarian and uterine oxidative stress and disruption of endocrine balance in rats. Journal of Basic Clinical Physiology and Pharmacology. Vol. 29 No. 2, 131-140.

[61] Adedara I.A., Abolaji A.O., Awogbindin I.O., Farombi E.O. (2017). Suppression of the brain-pituitary-testicular axis function following acute arsenic and manganese coexposure and withdrawal in rats. Journal of Trace Elements in Medicine and Biology Vol. 39, 21-29.

[63] Adedara I.A., Abolaji A.O., Ladipo E.O., Fatunmibi O.J., Abajingin A.O., Farombi E.O. (2017). 4-Vinylcyclohexene diepoxide disrupts sperm characteristics, endocrine balance and redox status in the testes and epididymis of rats. Redox Report Vol. 22 No. 6, 388-398.

[64] Abolaji A.O., Adedara I.A., Abajingin A.O., Fatunmibi O.J., Ladipo E.O., Farombi E.O. (2016). Evidence of oxidative damage and reproductive dysfunction accompanying 4-vinylcyclohexene diepoxide exposure in female Wistar rats. Reproductive Toxicology Vol. 66, 10-19.

[65] Abolaji A.O., Toloyai P.E., Odeley T.D., Akinduro S., Rocha J.B., Farombi E.O. (2016). Hepatic and renal toxicological evaluations of an industrial ovotoxic chemical, 4-vinylcyclohexene diepoxide, in both sexes of Wistar rats. Environmental Toxicology and Pharmacology Vol. 45, 28-40.

[66] Abolaji A.O., Adesanoye O.A., Awogbindin I., Farombi E.O. (2016). Endocrine disruption and oxidative stress implications of artemether-lumefantrine combination therapy in the ovary and uterus of rats. Human Experimental Toxicology. Vol. 35, No. 11,1173-1182.

[69] Adedara I.A., Abolaji A.O., Odion B.E., Omoloja A.A., Okwudi I.J., Farombi E.O. (2016). Redox status of the testes and sperm of rats following exposure to 2,5hexanedione. Redox Report. Vol. 21 No. 6, 239-47

[71] Abolaji A.O., Kamdem J.P., Lugokenski T.H., Farombi E.O., Souza D.O., Loreto E.L., Rocha J.B. (2015). Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster. Redox Biology Vol. 5, 328-339. (U.S.A).

[73] Abolaji, A.O., Kamdem, J.P., Lugokenski, T.H., Nascimento, T.K., Waczuk, E.P., Farombi, E.O., Loreto, E.L., Rocha J.B.T. (2014): Involvement of oxidative stress in 4vinylcyclohexene-induced toxicity in Drosophila melanogaster. Free Radical Biology and Medicine Vol. 71, 99-108. (United States of America).

[77] Farombi, E.O., Abolaji, A.O., Adedara, I.A., Soladogun, A., Salau, V., Oguaka, M. (2014): Oxidative stress and changes in antioxidative defence system in erythrocytes of female rats exposed to 2, 5-Hexanedione. Archives of Basic and Applied Medicine Vol. 2, 29-33 (Nigeria).

[79] Adedara I.A., Abolaji A.O., Odion B., Okwudi I., Omoloja A., Farombi E.O. (2014). Impairment of hepatic and renal functions by 2,5-hexanedione is accompanied by oxidative stress in rats. Journal of Toxicology 2014:239240. DOI: 10.1155/2014/239240

[93] Eteng, M.U., Ukpanukpong, R.U., Abolaji, A.O, Eyong, E.U., Egbung, E. (2008): Biochemical and histological alteration and effect of perfloxacin on Wistar rats reproductive function. Australian Journal of Basic and Applied Sciences Vol. 2 No. 3, 475-480. (Jordan).

[94] Eteng, M.U., Onwuka, F.C., Umoh, I.B., Abolaji, A.O. (2008): Trans-generational effects of cadmium toxicity on gonadal steroid levels and reproductive outcome of Wistar rats. Journal of Applied Sciences Research Vol. 4 No. 7, 925-928. (India).

7. Antimalarial Drug Safety and Malaria Research

The researcher's earliest sustained programme addressed a pressing regional health question: are widely used antimalarials safe? Through pharmacological, haematological and reproductive studies in rats - including standardisation of Artemisia annua by RP-HPLC and assessments of artemisinin, artemether-lumefantrine and artesunate-amodiaquine - the work flagged oxidative, hormonal and reproductive risks of these therapies, especially in pregnancy, and examined malaria parasite diversity and its effects in patients. Its contribution was to bring careful toxicological scrutiny to malaria treatment in an endemic setting.

Publications in this project:

[74] Abolaji A.O., Eteng M.U., Ebong P.E., Dar A., Farombi E.O., Choudhary M.I. (2014). Artemisia annua as a possible contraceptive agent: a clue from mammalian rat model. Natural Product Research Vol. 24, 2342-6. (Short communication, United Kingdom).

[75] Farombi, E.O., Adedara, I.A., Abolaji, A.O., Anamelechi, J.P., Sangodele, J.O. (2014): Sperm characteristics, antioxidant status and hormonal profile in rats treated with artemisinin. Andrologia Vol. 46 No. 8, 893-901. (Germany).

[78] Farombi, E.O., Abolaji, A.O., Adedara, I.A., Maduako, I., Omodanisi, I. (2014): Artemisinin induces hormonal imbalance and oxidative damage in the erythrocytes and uterus but not in the ovary of rats. Human and Experimental Toxicology Vol. 34 No. 1, 83-92 (United Kingdom).

[81] Abolaji, A.O., Eteng, M.U., Omonua, O., Adenrele, Y. (2013): Influence of coadministration of artemether and lumefantrine on selected plasma biochemical and erythrocyte oxidative stress indices in female Wistar rats. Human and Experimental Toxicology Vol. 32 No. 2, 206-15. (United Kingdom).

[82] Abolaji, A.O, Eteng, U.M., Ebong, P.E., Brisibe, E.A., Dar, A., Kabir N., Choudhary M.I. (2013): A safety assessment of the antimalarial herb Artemisia annua during pregnancy in Wistar rats. Phytotherapy Research Vol. 27 No. 5, 647-54. (United Kingdom).

[83] Eteng, M.U., Abolaji, A.O., Ebong, P.E., Brisibe, E.A., Dar A., Kabir N., Choudhary M.I. (2013): Biochemical and haematological evaluation of repeated dose exposure of male Wistar rats to an ethanolic extract of Artemisia annua. Phytotherapy Research Vol. 27 No. 4, 602-9. (United Kingdom).

[85] Abolaji, A.O., Osedeme, F., Olusemire, O. (2013): Artesunate-amodiaquine combination therapy in the absence of malarial parasite infection induces oxidative damage in female rats. Cell Biochemistry and Function Vol. 32, 303-308. (United Kingdom).

[86] Olasehinde, G.I., Yah, C.S., Singh, R, Ojurongbe, O. O., Ajayi, A.A., Valecha, N, Abolaji, A.O., Adebiyi, M.O., Adeyeba, O.A. (2012): Genetic diversity of Plasmodium falciparum field Isolates from Southwestern Nigeria. African Health Sciences Vol. 12 No. 3, 355-361. (Uganda).

[89] Eteng, M.U., Ekwe, A.O., Abolaji, A.O., Eyong, E.U., Ibekwe, H.A., Osuchukwu, N.C. (2010): Biochemical and haematological changes in pregnant malaria patients and pregnant non-malaria women. Scientific Research and Essays Vol. 5 No. 9, 1009-1013. (Nigeria).

[90] Abolaji, A.O., Eteng, M.U., Ebong, P.E., Brisibi, A., Shakil, A., Erum, S., Choudhary, M.I. (2010): Standardisation of Artemisia annua using Reversed Phase High Performance Liquid Chromatography (RP-HPLC). Pharmacognosy Journal Vol. 2 No. 7, 143-147. (India).

8. Diabetes, Aging and Lifespan Modulation

This strand used sucrose- and D-galactose-induced Drosophila models, together with a diabetic rat model, to probe metabolic dysfunction, oxidative aging and longevity. It demonstrated that antimicrobial/antidiabetic peptides (magainin-AM2, esculentin), the polyherbal antioxidant Jobelyn, apigenin and other plant products can attenuate hyperglycaemia, cognitive decline and lifespan shortening while extending survival. The work contributes mechanistic and intervention evidence linking diet, redox status and healthy aging, and identifies peptide and phytochemical leads for metabolic disease.

Publications in this project:

[18] Adebowale A, Oyaluna Z, Falobi AA, Abolaji AO, Olaiya CO, Ojo OO (2024). Magainin-AM2 inhibits sucrose-induced hyperglycaemia, oxidative stress, and cognitive dysfunction in Drosophila melanogaster. Free Radic Biol Med. S0891-5849(24)00545-8. doi: 10.1016/j.freeradbiomed.2024.06.028. Epub ahead of print. PMID: 38964592.

[32] John R, Abolaji AO, Adedara AO, Ajayi AM, Aderibigbe AO, Umukoro S. (2022). Jobelyn® extends the life span and improves motor function in Drosophila melanogaster exposed to lipopolysaccharide via augmentation of antioxidant status. Metabolic Brain Disease 37(4):1031-1040. doi: 10.1007/s11011-022-00919-4. Epub 2022 Feb 14.

[33] Adesanoye OA, Farodoye OM, Adedara AO, Falobi AA, Abolaji AO, Ojo OO. (2021). Beneficial actions of esculentin-2CHa(GA30) on high sucrose-induced oxidative stress in Drosophila melanogaster. Food and Chemical Toxicology 157:112620. doi: 10.1016/j.fct.2021.112620.

[39] Oyaluna, Z., Abolaji, A.O., Babalola, C.P. (2021). Effects of ruzu herbal bitters, a traditional nigerian polyherbal drug, on longevity and selected toxicological indices in Drosophila melanogaster. Biointerface Research in Applied Chemistry. 11(2), pp. 9638-9645

[48] Oyebode, O.T., Abolaji, A.O., Oluwadare, J.O., Adedara, A.O., Olorunsogo, O.O. (2020). Apigenin ameliorates D-galactose-induced lifespan shortening effects via antioxidative activity and inhibition of mitochondrial-dependent apoptosis in Drosophila melanogaster. Journal of Functional Foods, 69, 103957.

[95] Eteng, M.U., Bassey, B.J., Atangwho, I.J., Egbung, G.E., Eyong, E.U., Ebong, P.E., Abolaji, A.O. (2008): Biochemical indices of macrovascular complication in diabetic rat model: Compared effects of Vernonia amygdalina, Cathanrantus roseus and Chlorpropamide. Asian Journal of Biochemistry Vol. 3 No. 4, 228-234. (India).

9. Pesticide and Neurotoxicant Organ Toxicity in Mammalian Models

A mammalian-focused programme quantifying how pesticides and neurotoxicants - chlorpyrifos, carbendazim, acrylonitrile, fluoride and ethanol-potentiated manganese - inflict oxidative and inflammatory damage on the brain, liver, kidney and spleen, and how protective agents such as 6-gingerol-rich ginger fraction, curcumin and taurine can blunt these effects. The contribution is direct evidence on the multi-organ risks of common agrochemical and environmental exposures alongside accessible nutritional protectants.

Publications in this project:

[38] Nkpaa KW, Owoeye O, Amadi BA, Adedara IA, Abolaji AO, Wegwu MO, Farombi EO. (2021). Ethanol exacerbates manganese-induced oxidative/nitrosative stress, proinflammatory cytokines, nuclear factor-κB activation, and apoptosis induction in rat cerebellar cortex. Journal of Biochemical and Molecular Toxicology. 35(3):e22681. doi: 10.1002/jbt.22681.

[52] Farombi E.O., Abolaji A.O., Adetuyi B., Awosanya O., Fabusoro M. (2018). Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats. Journal of Basic Clinical Physiology and Pharmacology. doi: 10.1515/jbcpp-2018-0114

[58] Abolaji AO, Ojo M, Afolabi TT, Arowoogun MD, Nwawolor D, Farombi EO. (2017). Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats. Chemico-Biological Interactions. Vol. 270, 15-23.

[60] Adedara I.A., Abolaji A.O., Idris U.F., Olabiyi B.F., Onibiyo E.M., Ojuade T.D., Farombi E.O. (2017). Neuroprotective influence of taurine on sodium fluoride-induced biochemical and behavioral deficits in rats. Chemico-Biological Interactions Vol. 261, 1-10.

[62] Abolaji A.O., Awogbindin I.O., Adedara I.A., Farombi E.O. (2017). Insecticide chlorpyrifos and fungicide carbendazim, common food contaminants mixture, induces hepatic, renal, and splenic oxidative damage in female rats. Human and Experimental Toxicology Vol. 36, No. 5, 483-493.

10. Natural-Product Characterization, Phytochemistry and Ethnopharmacology

Running throughout the career, this broad programme characterised the phytochemistry, antioxidant capacity, cytotoxicity and safety of numerous medicinal plants (Chrysophyllum albidum, Rauwolfia vomitoria, Parinari polyandra, Anacardium, Euphorbia, garlic, Carpolobia lutea and others) using in vitro assays, human leukocytes, Drosophila and rodents, and reviewed plant-based neuroprotection against ischaemia-reperfusion. Including the earliest foundational biochemical and nutritional studies, it contributed a rich evidence base validating (and cautioning about) traditional remedies and supplied the candidate compounds deployed across the disease-model programmes above.

Publications in this project:

[9] Alaka HO, Ajayi TO, Abolaji AO (2025). Oxidative stress and fertility studies of selected plants using female Drosophila melanogaster. BMC Res Notes. 18(1):473. doi: 10.1186/s13104-025-07536-1.

[15] Oyaluna ZE, Abolaji AO, Bodede O, Olanlokun JO, Prinsloo G, Steenkamp P, Babalola CP. (2024). Chemical analysis of alliin-rich Allium sativum (garlic) extract and its safety evaluation in Drosophila melanogaster. https://doi.org/10.1016/j.toxrep.2024.101760.

[27] Omeiza NA, Bakre A, Ben-Azu B, Sowunmi AA, Abdulrahim HA, Chimezie J, Lawal SO, Adebayo OG, Alagbonsi AI, Akinola O, Abolaji AO, Aderibigbe AO. (2023). Mechanisms underpinning Carpolobia lutea G. Don ethanol extract's neurorestorative and antipsychotic-like activities in an NMDA receptor antagonist model of schizophrenia. J Ethnopharmacol. 301:115767. doi: 10.1016/j.jep.2022.115767.

[67] Kamdem J.P., Abolaji A.O., Elekofehinti O.O., Omotuyi I.O., Ibrahim M., Waseem Hassan, Barbosa N.V., Souza D.O., Rocha J.B. (2016). Therapeutic potential of plant extracts and phytochemicals against brain ischemia-reperfusion injury: A Review. The Natural Products Journal Vol. 6, No. 4, 250-284.

[72] Waczuk E.P., Kamdem J.P., Abolaji A.O., Meinerz D.F, Bueno D.C., Nascimento T.K., Dorow T.S., Boligon A.A., Athayde M.L., Rocha J.B., Avila D.S. (2015). Euphorbia tirucalli aqueous extract induces cytotoxicity, genotoxicity and changes in antioxidant gene expression in human leukocytes. Toxicology Research Vol 4, 739-748. (United Kingdom).

[76] Filho, V.M., Waczuk, P.W., Kamdem, J.P., Abolaji, A.O., Lacerda, S.R., Costa, J.G., Menezes, I.R., Boligon, A.A., Athayde, M.L., Rocha, J.B., Thais, P. (2014): Phytochemical constituents, antioxidant activity, cytotoxicity and osmotic fragility effects of Caju (Anacardium microcarpum). Industrial Crops and Products Vol. 55, 280-288. (Netherlands).

[80] Ogunbolude Y., Ibrahim M., Elekofehinti O.O., Adeniran A., Abolaji A.O., Rocha J.B.T., Kamdem J.P. (2014). Effects of Tapinanthus globiferus and Zanthoxylum zanthoxyloides extracts on human leukocytes in vitro. Journal of Intercultural Ethnopharmacology Vol. 3 No. 4, 167-172. (Turkey).

[87] Adebayo, A.H., Abolaji, A.O., Kela R., Oluremi, S.O., Owolabi, O.O., Ogungbe, O.A. (2011): Hepatoprotective activity of Chrysophyllum albidum against carbon tetrachloride-induced hepatic damage in rats. Canadian Journal of Pure and Applied Sciences Vol. 5 No. 3, 1597-1602. (Canada).

[88] Adebayo, A.H, Abolaji, A.O., Kela, S. Ayepola, O.O., Olorunfemi, T., Taiwo, O.S. (2011): Antioxidant activities of the leaves of Chrysophyllum albidum G. Pakistan Journal of Pharmaceutical Sciences Vol. 24 No. 4, 545-551. (Pakistan).

[91] Adebayo, A.H., Abolaji, A.O., Opata, T.K., Adegbenro, I.K. (2010): Effects of ethanolic leaves extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wistar rats. African Journal of Biotechnology Vol. 9 No. 14, 2145-2150. (Kenya).

[92] Eteng, M.U., Ibekwe, H.A., Abolaji, A.O., Okoi, A. I., Onwuka, F. C., Osuchukwu, N.C. (2009): Effect of Rauwolfia vomitoria Afzel (Apocynaceae) extract on serum amino transferase and alkaline phosphatase activities and selected indices of liver and kidney functions. African Journal of Biotechnology Vol. 8 No. 18, 4604-4607. (Kenya).

[96] Abolaji, A.O., Adebayo, A.H., Odesanmi, O.S. (2007): Effects of ethanolic fruit extract of Parinari polyandra (Rosaceae) on serum lipid profile and some electrolytes in pregnant rabbits. Research Journal of Medicinal Plant Vol. 1. No. 4, 121-127. (Kenya).

[97] Abolaji, A.O., Adebayo, A.H., Odesanmi, O.S. (2007): Nutritional qualities of three medicinal plant parts (Xylopia aethiopica, Blighia sapida and Parinari polyandra) commonly used by pregnant women in the western part of Nigeria. Pakistan Journal of Nutrition Vol. 6 No. 6, 665-668.

11. Computational Discovery and Personalized Disease Models (Cancer and Drug Targets)

The most recent and forward-looking strand couples wet-lab biology with computation and personalization. It includes personalised Drosophila 'avatars' built from African colorectal-cancer patients to guide therapy, integrative biochemical-molecular-computational discovery of protective hits against bisphenol toxicity, and in silico identification of anticancer peptides from a Drosophila selenoprotein. This work contributes a precision-medicine dimension - using patient-derived models and computational screening to accelerate the discovery of targeted treatments, with particular relevance to under-studied African patient populations.

Publications in this project:

[1] Oyeniyi, F.A., Oladokun FA, Ajayi AA, Ibrahim A, Aladeloye RS, Akinfe OA, Oludaiye FR, Moens TG, Badmos HA, Abolaji AO, Cagan R. Functional Exploration of African Colorectal Cancer Patients Using Personalised Drosophila Avatars. bioRxiv [Preprint]. 2026 Mar 30:2026.03.26.714433. doi: 10.64898/2026.03.26.714433. PMID: 41959337; PMCID: PMC13060073.

[2] Adeyemi, O. E., Monteiro, C. S., Emanuelli, T., Abolaji, A. O., Aguiyi, J. C., Jaryum, K. H., Johnson, T. O. (2026). Hydroxybenzoate-based hits from methanolic leaf fraction of Ficus exasperata Vahl: Integrative biochemical, molecular, and computational discovery against Bisphenol toxicity. Scientific Reports. https://doi.org/10.1038/s41598-026-62445-y

[47] Fatoki, T.H., Ibraheem, O., Abolaji, A.O., Sanni, D.M. (2020). In silico study of anticarcinogenic potential of the selenoprotein bthd from Drosophila melanogaster. Identifying the anticancer peptide CRSUR from the conserved region. Nova Biotechnologica et Chimica. 19(1), pp. 37-51

12. Research Metrics and Science Policy

A small but distinct contribution examining scientific productivity and the fairness of bibliometric evaluation among funded researchers in Brazil. These studies argued for more objective, field-adjusted metrics in assessing research performance, contributing to the meta-science and research-policy conversation on how scientists should be measured.

Publications in this project:

[54] Kamdem JP, Roos DH, Sanmi AA, Calabró L, Abolaji AO, de Oliveira CS, Barros LM, Duarte AE, Barbosa NV, Souza DO, Rocha JBT (2018). Productivity of CNPq Researchers from Different Fields in Biomedical Sciences: The Need for Objective Bibliometric Parameters-A Report from Brazil. Science and Engineering Ethics. doi: 10.1007/s11948-018-0025-5.

[68] Kamdem J.P., Abolaji A.O., Roos D.H., Calabró L., Barbosa N.V., Souza D.O., Rocha J.B. (2016). Scientific Performance of Brazilian Researchers in Pharmacology with grants from CNPq: A comparative study within the Brazilian categories. Anais Da Academia Brasileira De Ciencias. Vol 88 No. 3, 1735-1742.

Publications

 

SELECTED PUBLICATIONS

1. Oyeniyi, F.A., Oladokun FA, Ajayi AA, Ibrahim A, Aladeloye RS, Akinfe OA, Oludaiye FR, Moens TG, Badmos HA, Abolaji AO, Cagan R. Functional Exploration of African Colorectal Cancer Patients Using Personalised Drosophila Avatars. bioRxiv [Preprint]. 2026 Mar 30:2026.03.26.714433. doi: 10.64898/2026.03.26.714433. PMID: 41959337; PMCID: PMC13060073.

2. Adeyemi, O. E., Monteiro, C. S., Emanuelli, T., Abolaji, A. O., Aguiyi, J. C., Jaryum, K. H., Johnson, T. O. (2026). Hydroxybenzoate-based hits from methanolic leaf fraction of Ficus exasperata Vahl: Integrative biochemical, molecular, and computational discovery against Bisphenol toxicity. Scientific Reports. https://doi.org/10.1038/s41598-026-62445-y

3. Madu, J.C., Abolaji, A.O., Adaramoye, O.A. (2026). Co-Exposure of N-Methyl-N-Nitrosourea and Benzo[A]Pyrene Elicits Toxicity in Drosophila Melanogaster. Journal of Biochemical and Molecular Toxicology 40(6):e70915. doi: 10.1002/jbt.70915.

4. Otenaike, T.A., Farodoye, O.M., Rocha, J.B.T., Abolaji, A.O., Loreto, E.L.S. (2026). Mechanisms of nicotine toxicity and addiction-like behavior in Drosophila melanogaster: The role of α7 & β2 nicotinic acetylcholine receptor subunits in sensory valence and cellular stress. Neurotoxicology 115:103499. doi: 10.1016/j.neuro.2026.103499.

5. Farodoye OM, Otenaike TA, Mombach DM, Silva MM, Abolaji AO, Loreto ELDS. Diving Deeper into Mechanisms of Acrylamide-Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster. Environ Toxicol. 2026 Feb 23. doi: 10.1002/tox.70054. Epub ahead of print. PMID: 41725541.

6. Otenaike TA, Farodoye O, Silva KK, Abolaji AO (2026). Loreto ELS. E-cigarette exposure impairs associative memory: role of α7 and β2 nicotinic acetylcholine receptors. J Neurogenet. 23:1-18. doi: 10.1080/01677063.2026.2613797.

7. Oyibo A., Adedara-Balogun A., Ojo O.B., Molik Z.A., Otenaike T.A., Aschner M., Abolaji A.O. (2026). Harnessing Drosophila melanogaster to unravel micro/nanoplastics-induced neurotoxicity and protective mechanisms: A new frontier in environmental neurotoxicology. Advances in Neurotoxicology, Academic Press, 2026, ISSN 2468-7480, https://doi.org/10.1016/bs.ant.2026.03.007.

8. T. A., Farodoye, O. M., Olaniyan, H., Teibo, J. O., Faleke, H. A., Akinola, I. A., Molik, Z. A., Aschner, M., Abolaji, A. O. (2026). Neurotoxicity of heavy metals across the lifespan: The beneficial role of nutrition from fetus to the elderly. In Advances in Neurotoxicology, ISSN 2468-7480. Elsevier. https://doi.org/10.1016/bs.ant.2026.03.003

9. Alaka HO, Ajayi TO, Abolaji AO (2025). Oxidative stress and fertility studies of selected plants using female Drosophila melanogaster. BMC Res Notes. 18(1):473. doi: 10.1186/s13104-025-07536-1.

10. Otenaike TA, Farodoye OM, de Silva MM, Loreto JS, Adedara AO, Dos Santos MM, de Prestes AS, Barbosa NV, da Rocha JBT, Lobo LE, Wagner R, Abolaji AO, Loreto ELS (2024). Nicotine and Vape: Drugs of the Same Profile Flock Together. J Biochem Mol Toxicol. 38(12):e70075. doi: 10.1002/jbt.70075.

11. Abolaji AO, Adedara AO, Madu JC, Owalude OT, Ogunyemi OM, Omoboyowa DA, Omage FB, Whitworth AJ, Aschner M. Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson's disease. Sci Rep. 2025 May 22;15(1):17769. doi: 10.1038/s41598-025-00698-9. PMID: 40404673; PMCID: PMC12098997.

12. Okonta C, Ogunyemi OM, Olabuntu B, Abolaji AO. Ameliorative role of naringenin in MPTP- induced Parkinsonism: Insights from Drosophila melanogaster experimental model combined with computational biology. Toxicol Rep. 2025 Mar 20;14:102004. doi: 10.1016/j.toxrep.2025.102004. PMID: 40213420; PMCID: PMC11982306.

13. Akano JM, Molik ZA, Abolaji AO, Ogbole OO. Mitigating aluminum chloride-induced toxicity in Drosophila melanogaster with peptide fractions from Euphorbia species. Drug Chem Toxicol. 2025 May;48(3):687-696. doi: 10.1080/01480545.2024.2421916. Epub 2024 Nov 5. PMID: 39501706.

14. Ashaolu OP, Odukanmi OA, Salami AT, Abolaji AO, Olaleye SB. Kolaviron: a Bioflavonoid from Seed Extract of Garcinia kola Attenuates Chromium (VI)-Induced Gut Dysfunction and Oxidative Damage in Drosophila melanogaster. Biol Trace Elem Res. 2025 Jun;203(6):3366-3375. doi: 10.1007/s12011-024-04414-y. Epub 2024 Oct 19. PMID: 39425879.

15. Oyaluna ZE, Abolaji AO, Bodede O, Olanlokun JO, Prinsloo G, Steenkamp P, Babalola CP. (2024). Chemical analysis of alliin-rich Allium sativum (garlic) extract and its safety evaluation in Drosophila melanogaster. https://doi.org/10.1016/j.toxrep.2024.101760.

16. Asejeje FO, Asejeje GI, Ogunro OB, Adedara AO, Abolaji AO (2024). Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity. BMC Pharmacol Toxicol. 25(1):70. doi: 10.1186/s40360-024-00792-0. PMID: 39334451; PMCID: PMC11438368.

17. Farodoye OM, Otenaike TA, Loreto JS, Adedara AO, Silva MM, Barbosa NV, Rocha JBTD, Abolaji AO, Loreto ELS. (2024) Evidence of acrylamide-induced behavioral deficit, mitochondrial dysfunction and cell death in Drosophila melanogaster. Comp Biochem Physiol C Toxicol Pharmacol. 284:109971. doi: 10.1016/j.cbpc.2024.109971. Epub ahead of print. PMID: 38972620.

18. Adebowale A, Oyaluna Z, Falobi AA, Abolaji AO, Olaiya CO, Ojo OO (2024). Magainin-AM2 inhibits sucrose-induced hyperglycaemia, oxidative stress, and cognitive dysfunction in Drosophila melanogaster. Free Radic Biol Med. S0891-5849(24)00545-8. doi: 10.1016/j.freeradbiomed.2024.06.028. Epub ahead of print. PMID: 38964592.

19. Adedara AO, Bressan GN, Dos Santos MM, Fachinetto R, Abolaji AO, Barbosa NV. (2024). Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster.101:117-127. doi: 10.1016/j.neuro.2024.02.006.

20. Asejeje FO, Alade TF, Oyibo A, Abolaji AO. (2024). Toxicological assessment of sodium benzoate in Drosophila melanogaster. J Biochem Mol Toxicol. 38(1):e23586. doi: 10.1002/jbt.23586. Epub 2023 Nov 20. PMID: 37986221.

Supervision

SUPERVISION OF STUDENTS (Selected)

1. Name: Opeyemi Balogun (Ph.D.)
Title of Thesis: A Study of the Chemistry and some Biological Activities of Three Varieties of Plectranthus esculentus (N.E.Br) Tubers and Leaves. 
Department and Institution: Department of Pharmaceutical Chemistry, University of Jos.
Year of Ph.D. Graduation: 2021
Supervisors: Professor Alemika Taiwo; Prof. Amos Abolaji

2. Name: Aghogho Oyibo (Ph.D.)
Title of Thesis: Cytoremediative Potentials of Vitellaria paradoxa (Gaertn. C.F) in Arsenic-induced Toxicity in Wistar Rat, Harwich Fruit Fly and its Antiproliferative Activity in MCF-7 Cells.
Department and Institution: Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan.
Year of Ph.D. Graduation: 2021
Supervisors: Professor Oyeronke Odunola and Prof. Amos Abolaji

3. Name of Student: Adeola Adedara
Project Title: Effects of kaempferol hesperetin and hesperidin on MPTP- induced Parkinsonism:  Drosophila melanogaster as model organism.
Department and Institution: Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Brazil.
Year of Graduation: 2024
Supervisors: Professor Nilda Berenice Barbosa and Prof. Amos Abolaji

4. Name of Student: Judith Madu
Project Title: Interactive actions of N-Methyl-N-Nitrosourea and Benzo[a]pyrene induced oxidative stress in Drosophila melanogaster (M.Phil).
Department and Institution: Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan.
Year of M.Phil. Graduation: 2024
Supervisors: Professor O.A. Adaramoye and Prof. Amos Abolaji

5. Name of Student: Onaara Ashaolu
Title of Project:
Physiological Changes in the Gut of Oregon Strain of Drosophila melanogaster Following Consumption of Diets-Containing Selected Heavy Metals. Department and Institution: Department of Physiology, Faculty of Basic Medical Sciences, University of Ibadan.
Year of PhD Graduation: 2025
Supervisors: Professor S.B. Olaleye and Prof. Amos Abolaji

6. Name of Student: Zeniat Oyaluna
Title of Project: Therapeutic and Antimicrobial Evaluation Alliin-Rich Garlic Extract in Drosophila melanogaster Model of Sucrose-Induced Type 2 Diabetes.
Department and Institution: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan
Year of PhD Graduation: 2025
Supervisors: Professor Peace Chinedum Babalola and Prof.  Amos Abolaji

7. Name of Student: Zaynab Mohammed
Title: Neuroprotective properties of Bioactive Peptides from Selected Nigerian Medicinal Plants.
Department and Institution: Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan. Year of Entry: 2019
Supervisors: Prof. Omonike Ogbole and Prof. Amos Abolaji

Grants

Current Selected Research Grant 

1. Cambridge-Africa ALBORADA Research Fund, UK- FLY-NEUROCAN Workshop: Frontiers in Drosophila Research for Neurodegeneration and Cancer (2026).

2. International Centre for Genetic Engineering and Biotechnology, Trieste, Italy- FLY-NEUROCAN Workshop: Frontiers in Drosophila Research for Neurodegeneration and Cancer (2025-2026).

3. Company of Biologists, UK- FLY-NEUROCAN Workshop: Frontiers in Drosophila Research for Neurodegeneration and Cancer (2026).

4. Motsepe Foundation/Harvard University- Discovering the Molecular Mechanisms Underlying Toxicity of Environmental Pollutants in Nigeria. Harvard University (2023-2025).

5. CRP, International Centre for Genetic Engineering and Biotechnology (CRP-ICGEB), Trieste, Italy- Unravelling the molecular therapeutic mechanisms of resveratrol rescue-driven in Drosophila melanogaster models of Parkinson's Disease (2019-2024).

6. Committee for Aid and Education in Neurochemistry (Category 1B: Research Supplies for the applicant's home laboratory)- Possible chemopreventive mechanism of xanthophyll carotenoid astaxanthin (ATX) against neurotoxin MPTP-induced Parkinsonism in Drosophila melanogaster (2017).

7. Cambridge-Africa ALBORADA Research Fund- Building capacity for developmental biology research through analysis of the ovotoxic effects of 4-vinylcyclohexene (VCH) and its metabolites in the egg chamber of Drosophila melanogaster (2017).

8. International Centre for Genetic Engineering and Biotechnology (ICGEB) Workshop Grant-DrosAfrica ICGEB Course, “Drosophila melanogaster in Biomedical Research: Low Cost and Profitable”, University of Ibadan, Nigeria, 18-29 July 2017.

9. AXA Mansard Insurance-PIUTA Ibadan Centre Mini Fellowship- Biochemical mechanisms of toxicity of the ovotoxic carcinogen 7,12-dimethylbenz[a]anthracene in a Drosophila melanogaster model (2016).

10. Thomas-Basir Biomedical Foundation-Toxicological mechanisms of the ovotoxicant and carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) in Drosophila melanogaster (2015).

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